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J Appl Physiol 88: 863-870, 2000;
8750-7587/00 $5.00
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Vol. 88, Issue 3, 863-870, March 2000

Protective and defensive airway reflexes evoked by nasal exposure to wood smoke in anesthetized rats

C.-Y. Ho1,2 and Y. R. Kou1

1 Institute of Physiology, School of Medicine and Life Science, National Yang-Ming University, and 2 Department of Otolaryngology, Veterans General Hospital, Taipei, Taiwan 11221, Republic of China

We investigated the airway responses evoked by nasal wood smoke in anesthetized Sprague-Dawley rats. Wood smoke (5 ml, 1.4 ml/s) was delivered into an isolated nasal cavity while animals breathed spontaneously. In study 1, nasal wood smoke triggered either an apneic response (n = 26) or a sniff-like response (n = 16) within 1 s after smoke exposure in 42 normal rats. Both airway responses were abolished by trigeminal nerve denervation and by nasal application of a local anesthetic or a hydroxyl radical scavenger, but they were not significantly affected by removal of smoke particulates or nasal application of a saline vehicle. In study 2, nasal wood smoke only triggered a mild apneic response in two rats neonatally treated with capsaicin and had no effect on breathing in the other six; the treatment is known to chronically ablate C fibers and some Adelta fibers. In contrast, nasal wood smoke evoked an apneic response in six rats neonatally treated with the vehicle of capsaicin and elicited a sniff-like response in the other two. These results suggest that the apneic and sniff-like responses evoked by nasal wood smoke result from the stimulation of trigeminal nasal C-fiber and Adelta -fiber afferents by the gas-phase smoke and that hydroxyl radical is the triggering chemical factor.

nasal irritation; C fibers; gas phase; particulates; hydroxyl radical


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