Journal of Applied Physiology
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J Appl Physiol 88: 1119-1126, 2000;
8750-7587/00 $5.00
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Vol. 88, Issue 3, 1119-1126, March 2000

INVITED REVIEW
Transgenic animals in integrative biology: approaches and interpretations of outcome

R. Sanders Williams1 and Peter D. Wagner2

1 University of Texas Southwestern Medical Center, Dallas, Texas 75390-8573; and 2 University of California, San Diego, California 92093-0623

Technological innovations in methods for genetic manipulation of laboratory animals and in techniques for assessment of cardiovascular, respiratory, behavioral, and metabolic physiology in mouse models afford unprecedented opportunities for research in integrative biology. We provide here an overview of basic and advanced techniques for generation of transgenic mice and a discussion of how transgenic technology can be most advantageously applied to important physiological questions that can be addressed only within the intact organism.

transgenic mice; homologous recombination; gene knockout; cardiovascular physiology; respiratory physiology; conditional gene knockout


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