Journal of Applied Physiology AJP: Lung Cellular and Molecular Physiology
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J Appl Physiol 88: 1022-1028, 2000;
8750-7587/00 $5.00
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Vol. 88, Issue 3, 1022-1028, March 2000

Mechanical properties of the tracheal mucosal membrane in the rabbit. II. Morphometric analysis

Lu Wang1,2, Kenneth L. Pinder1, Joel L. Bert1, Mitsushi Okazawa2, and Peter D. Paré2

1 Department of Chemical and Bio-Resource Engineering, University of British Columbia, Vancouver V6T 1Z4; and 2 Pulmonary Research Laboratory, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada V6Z 1Y6

Folding of the airway mucosal membrane provides a mechanical load that impedes airway smooth muscle contraction. Mechanical testing of rabbit tracheal mucosal membrane showed that the membrane is stiffer in the longitudinal than in the circumferential direction of the airway. To explain this difference in the mechanical properties, we studied the morphological structure of the rabbit tracheal mucosal membrane in both longitudinal and circumferential directions. The collagen fibers were found to form a random meshwork, which would not account for differences in stiffness in the longitudinal and circumferential directions. The volume fraction of the elastic fibers was measured using a point-counting technique. The orientation of the elastic fibers in the tissue samples was measured using a new method based on simple geometry and probability. The results showed that the volume fraction of the elastic fibers in the rabbit tracheal mucosal membrane was ~5% and that the elastic fibers were mainly oriented in the longitudinal direction. Age had no statistically significant effect on either the volume fraction or the orientation of the elastic fibers. Linear correlations were found between the steady-state stiffness and the quantity of the elastic fibers oriented in the direction of testing.

elastin; collagen; imaging analysis


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