| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905
The
goal of this study was to merge the methods currently used to assess
beat-by-beat changes in muscle sympathetic nerve activity with a
signal-averaging approach and overcome the inherent subjectivity and
time-consuming nature of manual analysis of baroreflex-mediated sympathetic responses in humans. This is a retrospective study using
data obtained during two prior studies [J. R. Halliwill, J. A. Taylor, and D. L. Eckberg. J. Physiol. (Lond.) 495:
279-288, 1996; C. T. Minson, J. R. Halliwill, T. Young, and M. J. Joyner. FASEB J. 13: A1044, 1999]. Beat-by-beat arterial
pressure (Finapres device) and muscle sympathetic nerve activity
(microneurography) were recorded in seven healthy, nonsmoking,
normotensive subjects (2 men, 5 women) between the ages of 23 and 32 yr
during arterial pressure changes induced by bolus injections of
nitroprusside and phenylephrine. The muscle sympathetic nerve
activity-diastolic pressure relationship was analyzed by both the
traditional manual detection method and a novel segregated
signal-averaging method. The results show the two analysis approaches
are highly correlated across subjects (r = 0.914, P
< 0.05) and are in close agreement [slope for manual
detection 
6.17 ± 0.91 (SE) vs. slope for segregated signal
averaging 5.98 ± 0.83 total integrated
activity · beat
1 · mmHg1; P = 0.60]. However, a
considerable time savings is seen with the new method (min vs.
h). Segregated signal averaging as developed here provides a valid
alternative to "by-hand" analysis of beat-by-beat changes in
muscle sympathetic nerve activity that occur during dynamic
baroreflex-mediated changes in sympathetic outflow. This approach
provides an objective, rapid method to analyze nerve recordings.
muscle sympathetic nerve activity; sympathetic nervous system; signal processing; computer assisted; microneurography; microelectrodes
This article has been cited by other articles:
|
|
 |
|
  M. Ichinose, M. Saito, N. Fujii, T. Ogawa, K. Hayashi, N. Kondo, and T. Nishiyasu Modulation of the control of muscle sympathetic nerve activity during incremental leg cycling J. Physiol., June 1, 2008; 586(11): 2753 - 2766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cui, V. Mascarenhas, R. Moradkhan, C. Blaha, and L. I. Sinoway Effects of muscle metabolites on responses of muscle sympathetic nerve activity to mechanoreceptor(s) stimulation in healthy humans Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R458 - R466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cui, S. Durand, and C. G. Crandall Baroreflex control of muscle sympathetic nerve activity during skin surface cooling J Appl Physiol, October 1, 2007; 103(4): 1284 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. H. Simmons, J. M. Manson, and J. R. Halliwill Mild central chemoreflex activation does not alter arterial baroreflex function in healthy humans J. Physiol., September 15, 2007; 583(3): 1155 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Fu, R. P. Shook, K. Okazaki, J. L. Hastings, S. Shibata, C. L. Conner, M. D. Palmer, and B. D. Levine Vasomotor sympathetic neural control is maintained during sustained upright posture in humans J. Physiol., December 1, 2006; 577(2): 679 - 687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ichinose, M. Saito, N. Fujii, N. Kondo, and T. Nishiyasu Modulation of the control of muscle sympathetic nerve activity during severe orthostatic stress J. Physiol., November 1, 2006; 576(3): 947 - 958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, C. Blaha, R. Moradkhan, K. S. Gray, and L. I. Sinoway Muscle sympathetic nerve activity responses to dynamic passive muscle stretch in humans J. Physiol., October 15, 2006; 576(2): 625 - 634. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cui, M. Sathishkumar, T. E. Wilson, M. Shibasaki, S. L. Davis, and C. G. Crandall Spectral characteristics of skin sympathetic nerve activity in heat-stressed humans Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1601 - H1609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ichinose, M. Saito, N. Kondo, and T. Nishiyasu Time-dependent modulation of arterial baroreflex control of muscle sympathetic nerve activity during isometric exercise in humans Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1419 - H1426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Charkoudian, J. H. Eisenach, M. J. Joyner, S. K. Roberts, and D. E. Wick Interactions of plasma osmolality with arterial and central venous pressures in control of sympathetic activity and heart rate in humans Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2456 - H2460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Muenter Swift, N. Charkoudian, R. M. Dotson, G. A. Suarez, and P. A. Low Baroreflex control of muscle sympathetic nerve activity in postural orthostatic tachycardia syndrome Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1226 - H1233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Alvarez, J. R. Halliwill, T. P. Ballard, S. D. Beske, and K. P. Davy Sympathetic neural regulation in endurance-trained humans: fitness vs. fatness J Appl Physiol, February 1, 2005; 98(2): 498 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ichinose, M. Saito, T. Ogawa, K. Hayashi, N. Kondo, and T. Nishiyasu Modulation of control of muscle sympathetic nerve activity during orthostatic stress in humans Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2147 - H2153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Charkoudian, E. A. Martin, F. A. Dinenno, J. H. Eisenach, N. M. Dietz, and M. J. Joyner Influence of increased central venous pressure on baroreflex control of sympathetic activity in humans Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1658 - H1662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Alvarez, T. P. Ballard, S. D. Beske, and K. P. Davy Subcutaneous obesity is not associated with sympathetic neural activation Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H414 - H418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, R. Zhang, T. E. Wilson, and C. G. Crandall Spectral analysis of muscle sympathetic nerve activity in heat-stressed humans Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H1101 - H1106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ichinose, M. Saito, H. Wada, A. Kitano, N. Kondo, and T. Nishiyasu Modulation of arterial baroreflex control of muscle sympathetic nerve activity by muscle metaboreflex in humans Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H701 - H707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Alvarez, S. D. Beske, T. P. Ballard, and K. P. Davy Sympathetic Neural Activation in Visceral Obesity Circulation, November 12, 2002; 106(20): 2533 - 2536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Halliwill and C. T. Minson Effect of hypoxia on arterial baroreflex control of heart rate and muscle sympathetic nerve activity in humans J Appl Physiol, September 1, 2002; 93(3): 857 - 864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, T. E. Wilson, and C. G. Crandall Baroreflex modulation of sympathetic nerve activity to muscle in heat-stressed humans Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2002; 282(1): R252 - R258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, T. E. Wilson, M. Shibasaki, N. A. Hodges, and C. G. Crandall Baroreflex modulation of muscle sympathetic nerve activity during posthandgrip muscle ischemia in humans J Appl Physiol, October 1, 2001; 91(4): 1679 - 1686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Hamner and J. A. Taylor Automated quantification of sympathetic beat-by-beat activity, independent of signal quality J Appl Physiol, September 1, 2001; 91(3): 1199 - 1206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Torp, M. E. Tschakovsky, J. R. Halliwill, C. T. Minson, and M. J. Joyner {beta}-Receptor agonist activity of phenylephrine in the human forearm J Appl Physiol, May 1, 2001; 90(5): 1855 - 1859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, T. E. Wilson, and C. G. Crandall Baroreflex modulation of muscle sympathetic nerve activity during cold pressor test in humans Am J Physiol Heart Circ Physiol, May 1, 2002; 282(5): H1717 - H1723. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
