Journal of Applied Physiology
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J Appl Physiol 88: 761-766, 2000;
8750-7587/00 $5.00
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Vol. 88, Issue 2, 761-766, February 2000

Enhanced endothelium-dependent vasodilation in older endurance-trained men

Morton R. Rinder, Robert J. Spina, and Ali A. Ehsani

Division of Gerontology and Geriatrics and Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri 63110

We hypothesized that abnormal endothelium-dependent vasodilation (EDD) found in older otherwise healthy subjects can be attenuated with long-term endurance training. Ten endurance-trained men, 68.5 ± 2.3 yr old, and 10 healthy sedentary men, 64.7 ± 1.4 yr old, were studied. Aerobic exercise capacity (VO2 max), fasting plasma cholesterol, insulin, and homocysteine concentrations were measured. Master athletes had higher VO2 max (42 ± 2.3 vs. 27 ± 1.4 ml · kg-1 · min-1, P < 0.001), slightly higher total cholesterol (226 ± 8 vs. 199 ± 8 mg/dl, P = 0.05), similar insulin, and higher homocysteine (10.7 ± 1.3 vs. 9.2 ± 1.4 µmol/ml, p = 0.02) concentrations. Brachial arterial diameter, determined with vascular ultrasound, during the hyperemic response was greater in the master athletes than in controls (P = 0.005). Peak vasodilatory response was 109.1 ± 2 vs. 103.6 ± 2% (P < 0.05) in the athletes and controls, respectively. Endothelium-independent vasodilation in response to nitroglycerin was similar between the two groups. The increased arterial diameter during the hyperemic response correlated significantly with the VO2 max in the entire population (r = 0.66, P < 0.002). Our results suggest that long-term endurance exercise training in older men is associated with systemic enhanced EDD, which is even detectable in the conduit arteries of untrained muscle.

training; elderly


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