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J Appl Physiol 88: 713-721, 2000;
8750-7587/00 $5.00
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Vol. 88, Issue 2, 713-721, February 2000

Carbonic anhydrase inhibition delays plasma lactate appearance with no effect on ventilatory threshold

Barry W. Scheuermann1, John M. Kowalchuk1,2, Donald H. Paterson1, and David A. Cunningham1,2

1 Centre for Activity and Ageing, School of Kinesiology, and 2 Department of Physiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7

The effect of carbonic anhydrase (CA) inhibition with acetazolamide (Acz, 10 mg/kg body wt iv) on exercise performance and the ventilatory (VET) and lactate (LaT) thresholds was studied in seven men during ramp exercise (25 W/min) to exhaustion. Breath-by-breath measurements of gas exchange were obtained. Arterialized venous blood was sampled from a dorsal hand vein and analyzed for plasma pH, PCO2, and lactate concentration ([La-]pl). VET [expressed as O2 uptake (VO2), ml/min] was determined using the V-slope method. LaT (expressed as VO2, ml/min) was determined from the work rate (WR) at which [La-]pl increased 1.0 mM above rest levels. Peak WR was higher in control (Con) than in Acz sutdies [339 ± 14 vs. 315 ± 14 (SE) W]. Submaximal exercise VO2 was similar in Acz and Con; the lower VO2 at exhaustion in Acz than in Con (3.824 ± 0.150 vs. 4.283 ± 0.148 l/min) was appropriate for the lower WR. CO2 output (VCO2) was lower in Acz than in Con at exercise intensities >= 125 W and at exhaustion (4.375 ± 0.158 vs. 5.235 ± 0.148 l/min). [La-]pl was lower in Acz than in Con during submaximal exercise >= 150 W and at exhaustion (7.5 ± 1.1 vs. 11.5 ± 1.1 mmol/l). VET was similar in Acz and Con (2.483 ± 0.086 and 2.362 ± 0.110 l/min, respectively), whereas the LaT occurred at a higher VO2 in Acz than in Con (2.738 ± 0.223 vs. 2.190 ± 0.235 l/min). CA inhibition with Acz is associated with impaired elimination of CO2 during the non-steady-state condition of ramp exercise. The similarity in VET in Con and Acz suggests that La- production is similar between conditions but La- appearance in plasma is reduced and/or La- uptake by other tissues is enhanced after the Acz treatment.

ramp exercise; acetazolamide; exercise performance; acid-base status


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