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J Appl Physiol 88: 649-654, 2000;
8750-7587/00 $5.00
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Vol. 88, Issue 2, 649-654, February 2000

Effects of swimming training on three superoxide dismutase isoenzymes in mouse tissues

Chitose Nakao1,2, Tomomi Ookawara2, Takako Kizaki2, Shuji Oh-Ishi2, Hiromi Miyazaki3, Shuhkoh Haga3, Yuzo Sato1, Li Li Ji4, and Hideki Ohno2

1 Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464-0814; 2 Department of Hygiene, National Defense Medical College, Tokorozawa 359-8513; 3 Institute of Health and Sport Science, University of Tsukuba, Tsukuba 305-0006, Japan; and 4 Department of Kinesiology, School of Education, University of Wisconsin, Madison, Wisconsin 53706

The purpose of the present study was to investigate the effects of swimming training on the changes in three superoxide dismutase (SOD) isoenzymes in mice. The trained mice underwent a 6-wk swimming program (1 h/day, 5 days/wk) in water at 35-36°C. Immunoreactive extracellular SOD (EC-SOD), copper- and zinc-containing SOD (CuZn-SOD), and manganese-containing SOD (Mn-SOD) contents and their mRNA abundance were determined in serum, heart, lung, liver, kidney, and gastrocnemius muscle. EC-SOD content in liver and kidney was significantly increased with training. After training, CuZn-SOD content rose significantly only in kidney but decreased significantly in heart, lung, and liver. Mn-SOD content showed a significant increase in lung, kidney, and skeletal muscle but a significant decrease in liver. In most tissues, however, the changes in SOD isoenzyme contents were not concomitant with those in their mRNA levels. The results obtained thus suggest that, except for kidney, the responses in mouse tissues of three SOD isoenzymes (protein levels and mRNA abundance) to swimming training are different and that kidney may be one of the most sensitive organs to adapt to oxidative stress during physical training, although the mechanism remains vague.

extracellular superoxide dismutase; mRNA; affinity for heparin


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