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Unité de Bioénergétique et Environnement, Centre de Recherches du Service de Santé des Armées, 38702 La Tronche, France
This study investigated the effects of
voluntary wheel running on the myosin heavy chain (MHC) composition of
the soleus (Sol) and plantaris muscles (Pla) in rats developing under
hypobaric choronic hypoxia (CH) conditions during 4 wk in comparison
with those of control rats maintained under local barometric pressure conditions (C) or rats pair-fed an equivalent quantity of food to that
consumed by CH animals (PF). Compared with C animals, sedentary rats
subjected to CH conditions showed a significant decrease in type I MHC
in Sol (
12%, P < 0.01). Although strongly decreased
under hypoxia, spontaneous running activity increased the
expression of type I MHC (P < 0.01) so that no difference in
the MHC profile of Sol was shown between CH active and C active rats.
The MHC distribution in Sol of PF rats was not significantly different
from that found in C animals. CH resulted in a significant decrease in
type I (P < 0.01) and type IIA (P < 0.005) MHC,
concomitant with an increase in type IIB MHC in Pla (P < 0.001), compared with C and PF animals. In contrast to results in Sol
muscle, this slow-to-fast shift in the MHC profile was unaffected by
spontaneous running activity. These results suggest that running
exercise suppresses the hypoxia-induced slow-to-fast transition in the MHC expression in Sol muscles only. The hypoxia-induced decrease in
food intake has no major influence on MHC expression in developing rats.
simulated altitude; immunohistochemistry; electrophoresis; caloric intake; exercise wheel
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