Journal of Applied Physiology Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 88: 82-90, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Newman, J. P.
Right arrow Articles by Hanson, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Newman, J. P.
Right arrow Articles by Hanson, M. A.
Vol. 88, Issue 1, 82-90, January 2000

Hemodynamic and metabolic responses to moderate asphyxia in brain and skeletal muscle of late-gestation fetal sheep

J. P. Newman1, D. M. Peebles1, S. R. G. Harding2, R. Springett3, and M. A. Hanson1

Departments of 1 Obstetrics and Gynaecology, 2 Paediatrics, and 3 Medical Physics and Bioengineering, University College London, London WC1E 6HX, United Kingdom

The purpose of this study was to investigate metabolic and hemodynamic responses in two fetal tissues, hindlimb muscle and brain, to an episode of acute moderate asphyxia. Near-infrared spectroscopy was used to measure changes in total hemoglobin concentration ([tHb]) and the redox state of cytochrome oxidase (COX) simultaneously in the brain and hindlimb of near-term unanesthetized fetal sheep in utero. Oxygen delivery (DO2) to, and consumption (VO2) by, each tissue was derived from the arteriovenous difference in oxygen content and blood flow, measured by implanted flow probes. One hour of moderate asphyxia (n = 11), caused by occlusion of the maternal common internal iliac artery, led to a significant fall in DO2 to both tissues and to a significant drop in VO2 by the head. This was associated with an initial fall in redox state COX in the leg but an increase in the brain. [tHb], and therefore blood volume, fell in the leg and increased in the brain. These data suggest the presence of a fetal metabolic response to hypoxia, which, in the brain, occurs rapidly and could be neuroprotective.

cytochrome oxidase; near-infrared spectroscopy; neuroprotection; blood flow


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Bennet, V. Roelfsema, J. M. Dean, G. Wassink, G. G. Power, E. C. Jensen, and A. J. Gunn
Regulation of cytochrome oxidase redox state during umbilical cord occlusion in preterm fetal sheep
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1569 - R1576.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
L. Bennet, V. Roelfsema, P. Pathipati, J. S. Quaedackers, and A. J. Gunn
Relationship between evolving epileptiform activity and delayed loss of mitochondrial activity after asphyxia measured by near-infrared spectroscopy in preterm fetal sheep
J. Physiol., April 1, 2006; 572(1): 141 - 154.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. A. L Gallagher, J. P Newman, L. R Green, and M. A Hanson
The effect of low protein diet in pregnancy on the development of brain metabolism in rat offspring
J. Physiol., October 15, 2005; 568(2): 553 - 558.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online