Journal of Applied Physiology Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 88: 54-60, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (14)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chen, R.
Right arrow Articles by Macklem, P. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, R.
Right arrow Articles by Macklem, P. T.
Vol. 88, Issue 1, 54-60, January 2000

Twitch transdiaphragmatic pressure depends critically on thoracoabdominal configuration

Rongchang Chen, Bengt Kayser, Sheng Yan, and Peter T. Macklem

Meakins-Christie Laboratories, Montreal Chest Institute, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H2X 2P4

We measured the effect of thoracoabdominal configuration on twitch transdiaphragmatic pressure (Pdi, t) in response to supramaximal, transcutaneous, bilateral phrenic nerve shocks in three thin normal men. Pdi, t was measured as a function of lung volume (VL) in the relaxation configuration, at functional residual capacity (FRC), and at the same end-tidal VL 1) during relaxation; 2) with the abdomen (Ab) expanded and the rib cage (RC) in its relaxed FRC configuration; 3) with RC expanded and Ab in its relaxed FRC configuration; and 4) in configuration 3 with an active transdiaphragmatic pressure similar to that required to produce configuration 2. In increasing VL from FRC to configuration 1, Pdi, t decreased by 3.6 cmH2O; to configuration 2 by 14.8 cmH2O; to configuration 3 by 3.7 cmH2O; and to configuration 4 by 2.7 cmH2O. We argue that changes in velocity of shortening and radius of curvature are unlikely to account for these effects and suggest that changes in diaphragmatic fiber length (Ldi) are primarily responsible. If so, equivolume displacements of Ab and RC change Ldi in a ratio of ~4:1. We conclude that Pdi, t is exquisitely sensitive to abdominal displacements that must be rigorously controlled if Pdi, t is to be used to assess diaphragmatic contractility.

abdomen; rib cage; diaphragmatic contractility; phrenic stimulation; diaphragm fiber length


This article has been cited by other articles:


Home page
 J. Physiol.Home page
I. Vogiatzis, O. Georgiadou, M. Koskolou, D. Athanasopoulos, K. Kostikas, S. Golemati, H. Wagner, C. Roussos, P. D. Wagner, and S. Zakynthinos
Effects of hypoxia on diaphragmatic fatigue in highly trained athletes
J. Physiol., May 15, 2007; 581(1): 299 - 308.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Straus, C. Locher, M. Zelter, J.-P. Derenne, and T. Similowski
Facilitation of the diaphragm response to transcranial magnetic stimulation by increases in human respiratory drive
J Appl Physiol, September 1, 2004; 97(3): 902 - 912.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. Verin, E. Ross, A. Demoule, N. Hopkinson, A. Nickol, B. Fauroux, J. Moxham, T. Similowski, and M. I. Polkey
Effects of exhaustive incremental treadmill exercise on diaphragm and quadriceps motor potentials evoked by transcranial magnetic stimulation
J Appl Physiol, January 1, 2004; 96(1): 253 - 259.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Aliverti, G. Ghidoli, R. L. Dellaca, A. Pedotti, and P. T. Macklem
Chest wall kinematic determinants of diaphragm length by optoelectronic plethysmography and ultrasonography
J Appl Physiol, February 1, 2003; 94(2): 621 - 630.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
W.D-C. Man, Y-M. Luo, N. Mustfa, G.F. Rafferty, J-C. Glerant, M.I. Polkey, and J. Moxham
Postprandial effects on twitch transdiaphragmatic pressure
Eur. Respir. J., September 1, 2002; 20(3): 577 - 580.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. Verin, C. Straus, A. Demoule, P. Mialon, J.-P. Derenne, and T. Similowski
Validation of improved recording site to measure phrenic conduction from surface electrodes in humans
J Appl Physiol, March 1, 2002; 92(3): 967 - 974.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. Verin, F. Series, C. Locher, C. Straus, M. Zelter, J.-P. Derenne, and T. Similowski
Effects of neck flexion and mouth opening on inspiratory flow dynamics in awake humans
J Appl Physiol, January 1, 2002; 92(1): 84 - 92.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Aliverti, I. Iandelli, R. Duranti, S. J. Cala, B. Kayser, S. Kelly, G. Misuri, A. Pedotti, G. Scano, P. Sliwinski, et al.
Respiratory muscle dynamics and control during exercise with externally imposed expiratory flow limitation
J Appl Physiol, May 1, 2002; 92(5): 1953 - 1963.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online