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J Appl Physiol 88: 26-34, 2000;
8750-7587/00 $5.00
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Vol. 88, Issue 1, 26-34, January 2000

Nandrolone decanoate does not enhance training effects but increases IGF-I mRNA in rat diaphragm

Ghislaine Gayan-Ramirez1, Hélène Rollier1, Frank Vanderhoydonc2, Guido Verhoeven2, Rik Gosselink1, and Marc Decramer1

1 Respiratory Muscle Research Unit, Laboratory of Pneumology, and 2 Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

To examine whether concomitant anabolic steroid treatment combined with training might enhance previously observed training effects (A. Bisschop, G. Gayan-Ramirez, H. Rollier, R. Gosselink, R. Dom, V. de Bock, and M. Decramer. Am. J. Respir. Crit. Care Med. 155: 1583-1589, 1997) and whether insulin-like growth factor I (IGF-I) was involved in these changes, male and female rats were submitted to inspiratory muscle training (IMT) for 8 wk (30 min/day, 5 times/wk) and were compared with untrained controls. During the last 5 wk of training, trained rats were divided to receive weekly either low-dose (LD; 1.5 mg/kg) or high-dose (HD; 7.5 mg/kg) nandrolone decanoate or saline for the IMT and control rats. In both sexes, diaphragm muscle mass and contractile properties were unchanged with treatment. In males, HD resulted in decreased diaphragm type I cross-sectional area (-15%; P < 0.05, HD vs. IMT), whereas no changes were observed in females. Finally, an increase in IGF-I mRNA levels was present in HD male (+73%; P < 0.05, HD vs. IMT) and female treated rats [LD (+58%) and HD (+96%) vs. IMT; P < 0.001]. We conclude that administration of nandrolone decanoate did not enhance the previously observed training effects in rat diaphragm, although it increased the IGF-I mRNA expression levels.

intermittent resistive inspiratory loading; chest wall mechanics; insulin-like growth factor I mRNA


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