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J Appl Physiol 88: 173-179, 2000;
8750-7587/00 $5.00
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Vol. 88, Issue 1, 173-179, January 2000

IL-10 reduces grain dust-induced airway inflammation and airway hyperreactivity

Timothy J. Quinn1, Somer Taylor1, Christine L. Wohlford-Lenane1, and David A. Schwartz1,2

1 Pulmonary, Critical Care, and Occupational Medicine Division, Department of Internal Medicine, University of Iowa, and 2 Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242

To determine whether interleukin-10 (IL-10) could alter the development of grain dust-induced airway disease, we pretreated mice with either saline or IL-10 intravenously, exposed the mice to an inhalation challenge with corn dust extract (CDE), and measured inflammation and the development of airway hyperreactivity. Pretreatment with IL-10, in comparison to saline, reduced the concentration and percentage of polymorphonuclear cells in the lavage fluid 30 min after the inhalation challenge with CDE (P < 0.05). In comparison to saline-treated mice, IL-10 did not significantly alter the degree of airway hyperreactivity 30 min after the exposure to CDE. IL-10-treated mice lavaged 18 h after challenge with CDE also exhibited a lower percentage of polymorphonuclear cells in the lavage fluid (P < 0.05) and had significantly less airway hyperreactivity than did mice pretreated with the saline placebo (P < 0.05). These findings indicate that exogenous IL-10 is effective in reducing airway inflammation and airway hyperreactivity due to the inhalation of CDE.

interleukin-10; neutrophils; asthma; lipopolysaccharide


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