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J Appl Physiol 88: 109-112, 2000;
8750-7587/00 $5.00
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Vol. 88, Issue 1, 109-112, January 2000

Effect of creatine loading on neuromuscular fatigue threshold

Jeffrey Stout1, Joan Eckerson1, Kyle Ebersole2, Geri Moore1, Sharon Perry2, Terry Housh2, Anthony Bull2, Joel Cramer2, and Ash Batheja3

1 Exercise Science Department, Creighton University, Omaha 68178; 2 Center for Youth Fitness and Sports Research, University of Nebraska, Lincoln 68588; and 3 Department of Physical Therapy, University of Nebraska Medical Center, Omaha, Nebraska 68198

The purpose of this investigation was to determine the effect of creatine (Cr) loading on the onset of neuromuscular fatigue by monitoring electromyographic fatigue curves from the vastus lateralis muscle using the physical working capacity at the fatigue threshold (PWCFT) test. Using a double-blind random design, 15 women athletes [mean age 19.0 ± 2.0 (SD) yr] from the university crew team received a placebo (n = 8; 20 g glucose) or Cr (n = 7; 5 g Cr monohydrate + 20 g glucose) four times per day for 5 consecutive days. Analysis of covariance was used to analyze the data (covaried for presupplementation PWCFT values). The adjusted mean postsupplementation PWCFT value for the Cr group (mean = 186 W) was significantly (P < 0.05) higher than that of the placebo group (mean = 155 W). These findings suggest that Cr loading may delay the onset of neuromuscular fatigue.

ergogenic aid; electromyography; cycle ergometry; muscle fatigue


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A. M. Jones, H. Carter, J. S. M. Pringle, and I. T. Campbell
Effect of creatine supplementation on oxygen uptake kinetics during submaximal cycle exercise
J Appl Physiol, June 1, 2002; 92(6): 2571 - 2577.
[Abstract] [Full Text] [PDF]


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