Journal of Applied Physiology AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 88: 102-108, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (25)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fedele, M. J.
Right arrow Articles by Farrell, P. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fedele, M. J.
Right arrow Articles by Farrell, P. A.
Vol. 88, Issue 1, 102-108, January 2000

Severe diabetes prohibits elevations in muscle protein synthesis after acute resistance exercise in rats

Mark J. Fedele, Jazmir M. Hernandez, Charles H. Lang, Thomas C. Vary, Scot R. Kimball, Leonard S. Jefferson, and Peter A. Farrell

Noll Physiological Research Center and Department of Kinesiology, Pennsylvania State University, University Park 16802; and Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033

This study determined whether rates of protein synthesis increase after acute resistance exercise in skeletal muscle from severely diabetic rats. Previous studies consistently show that postexercise rates of protein synthesis are elevated in nondiabetic and moderately diabetic rats. Severely diabetic rats performed acute resistance exercise (n = 8) or remained sedentary (n = 8). A group of nondiabetic age-matched rats served as controls (n = 9). Rates of protein synthesis were measured 16 h after exercise. Plasma glucose concentrations were >500 mg/dl in the diabetic rats. Rates of protein synthesis (nmol phenylalanine incorporated · g muscle-1 · h-1, means ± SE) were not different between exercised (117 ± 7) and sedentary (106 ± 9) diabetic rats but were significantly (P < 0.05) lower than in sedentary nondiabetic rats (162 ± 9) and in exercised nondiabetic rats (197 ± 7). Circulating insulin concentrations were 442 ± 65 pM in nondiabetic rats and 53 ± 11 and 72 ± 19 pM in sedentary and exercised diabetic rats, respectively. Plasma insulin-like growth factor I concentrations were reduced by 33% in diabetic rats compared with nondiabetic rats, and there was no difference between exercised and sedentary diabetic rats. Muscle insulin-like growth factor I was not affected by resistance exercise in diabetic rats. The results show that there is a critical concentration of insulin below which rates of protein synthesis begin to decline in vivo. In contrast to previous studies using less diabetic rats, severely diabetic rats cannot increase rates of protein synthesis after acute resistance exercise.

hypoinsulinemia; anabolic factors; stress


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
R. Koopman and L. J. C. van Loon
Aging, exercise, and muscle protein metabolism
J Appl Physiol, June 1, 2009; 106(6): 2040 - 2048.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. J. Morrison, D. Hara, Z. Ding, and J. L. Ivy
Adding protein to a carbohydrate supplement provided after endurance exercise enhances 4E-BP1 and RPS6 signaling in skeletal muscle
J Appl Physiol, April 1, 2008; 104(4): 1029 - 1036.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. M. Lehti, M. Silvennoinen, R. Kivela, H. Kainulainen, and J. Komulainen
Effects of streptozotocin-induced diabetes and physical training on gene expression of titin-based stretch-sensing complexes in mouse striated muscle
Am J Physiol Endocrinol Metab, February 1, 2007; 292(2): E533 - E542.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. M. Lehti, M. Silvennoinen, R. Kivela, H. Kainulainen, and J. Komulainen
Effects of streptozotocin-induced diabetes and physical training on gene expression of extracellular matrix proteins in mouse skeletal muscle
Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E900 - E907.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Prod'homme, C. Rochon, M. Balage, H. Laurichesse, I. Tauveron, C. Champredon, P. Thieblot, J. Beytout, and J. Grizard
Whole body leucine flux in HIV-infected patients treated with or without protease inhibitors
Am J Physiol Endocrinol Metab, April 1, 2006; 290(4): E685 - E693.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Kubica, D. R. Bolster, P. A. Farrell, S. R. Kimball, and L. S. Jefferson
Resistance Exercise Increases Muscle Protein Synthesis and Translation of Eukaryotic Initiation Factor 2B{epsilon} mRNA in a Mammalian Target of Rapamycin-dependent Manner
J. Biol. Chem., March 4, 2005; 280(9): 7570 - 7580.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Prod'homme, M. Balage, E. Debras, M.-C. Farges, S. Kimball, L. Jefferson, and J. Grizard
Differential effects of insulin and dietary amino acids on muscle protein synthesis in adult and old rats
J. Physiol., February 15, 2005; 563(1): 235 - 248.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. D. Fluckey, E. E. Dupont-Versteegden, M. Knox, D. Gaddy, P. A. Tesch, and C. A. Peterson
Insulin facilitation of muscle protein synthesis following resistance exercise in hindlimb-suspended rats is independent of a rapamycin-sensitive pathway
Am J Physiol Endocrinol Metab, December 1, 2004; 287(6): E1070 - E1075.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. M. J. O'Connor, J. A. Bush, A. Suryawan, H. V. Nguyen, and T. A. Davis
Insulin and amino acids independently stimulate skeletal muscle protein synthesis in neonatal pigs
Am J Physiol Endocrinol Metab, January 1, 2003; 284(1): E110 - E119.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. R. Kimball, P. A. Farrell, and L. S. Jefferson
Exercise Effects on Muscle Insulin Signaling and Action: Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise
J Appl Physiol, September 1, 2002; 93(3): 1168 - 1180.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Balage, S. Sinaud, M. Prod'Homme, D. Dardevet, T. C. Vary, S. R. Kimball, L. S. Jefferson, and J. Grizard
Amino acids and insulin are both required to regulate assembly of the eIF4E {middle dot} eIF4G complex in rat skeletal muscle
Am J Physiol Endocrinol Metab, September 1, 2001; 281(3): E565 - E574.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B Esmarck, J L Andersen, S Olsen, E A Richter, M Mizuno, and M Kjaer
Timing of postexercise protein intake is important for muscle hypertrophy with resistance training in elderly humans
J. Physiol., August 15, 2001; 535(1): 301 - 311.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. D. Tipton, B. B. Rasmussen, S. L. Miller, S. E. Wolf, S. K. Owens-Stovall, B. E. Petrini, and R. R. Wolfe
Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise
Am J Physiol Endocrinol Metab, August 1, 2001; 281(2): E197 - E206.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. C. Kostyak, S. R. Kimball, L. S. Jefferson, and P. A. Farrell
Severe diabetes inhibits resistance exercise-induced increase in eukaryotic initiation factor 2B activity
J Appl Physiol, July 1, 2001; 91(1): 79 - 84.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. J. Fedele, C. H. Lang, and P. A. Farrell
Immunization against IGF-I prevents increases in protein synthesis in diabetic rats after resistance exercise
Am J Physiol Endocrinol Metab, June 1, 2001; 280(6): E877 - E885.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. J. Fedele, T. C. Vary, and P. A Farrell
Plasticity in Skeletal, Cardiac, and Smooth Muscle: Selected Contribution: IGF-I antibody prevents increases in protein synthesis in epitrochlearis muscles from refed, diabetic rats
J Appl Physiol, March 1, 2001; 90(3): 1166 - 1173.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. A. Farrell, J. M. Hernandez, M. J. Fedele, T. C. Vary, S. R. Kimball, and L. S. Jefferson
Eukaryotic initiation factors and protein synthesis after resistance exercise in rats
J Appl Physiol, March 1, 2000; 88(3): 1036 - 1042.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. M. Hernandez, M. J. Fedele, and P. A. Farrell
Time course evaluation of protein synthesis and glucose uptake after acute resistance exercise in rats
J Appl Physiol, March 1, 2000; 88(3): 1142 - 1149.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online