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J Appl Physiol 87: 2305-2310, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 6, 2305-2310, December 1999

Influence of mild exercise at the lactate threshold on glucose effectiveness

Makoto Sakamoto, Yasuki Higaki, Yuichiro Nishida, Akira Kiyonaga, Munehiro Shindo, Kumpei Tokuyama, and Hiroaki Tanaka

Laboratory of Exercise Physiology, Faculty of Health and Sports Science, Fukuoka University, Fukuoka 814-0133; Department of Community Health Science, Saga Medical School, Saga 849-8501; and Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan

The effect of a single bout of mild exercise on glucose effectiveness (SG) and insulin sensitivity (SI) was studied in six young male subjects by using a minimal model. An intravenous glucose tolerance test was performed under two conditions as follows: 1) 25 min after a bout of exercise on a cycle ergometer at the lactate threshold level for 60 min (Ex) and 2) without any prior exercise (Con). Leg blood flow (LBF) was also measured by strain-gauge plethysmography simultaneously with blood sampling. SI did not significantly change after exercise (18.1 ± 1.5 vs. 17.7 ± 1.9 × 10-5 min/pM), whereas SG significantly increased (0.016 ± 0.002 vs. 0.025 ± 0.002 min-1, P < 0.01). The increased blood flow after exercise remained high during the time period for measurement of the glucose disappearance constant and may be a determinant of SG. The incremental lactate area under the curve until insulin loading was also significantly higher in Ex than in Con (2.6 ± 0.9 vs. -3.5 ± 1.5 mM/min, P < 0.05). These results suggest that increased SG after mild exercise may be due, at least in part, to increased LBF and lactate production under a hyperglycemic state.

insulin sensitivity; minimal model; mild exercise


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