Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 87: 2296-2304, 1999;
8750-7587/99 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Davey, M. G.
Right arrow Articles by Harding, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Davey, M. G.
Right arrow Articles by Harding, R.
Vol. 87, Issue 6, 2296-2304, December 1999

Respiratory function in lambs after in utero treatment of lung hypoplasia by tracheal obstruction

M. G. Davey1, S. B. Hooper1, M. L. Tester1, D. P. Johns2, and R. Harding1

1 Fetal and Neonatal Research Unit, Department of Physiology, Monash University, Clayton, Victoria 3168; and 2 Department of Respiratory Medicine, Alfred Hospital, Prahran, Victoria 3181, Australia

Tracheal obstruction (TO) stimulates growth of hypoplastic lungs in the fetus, but there is little knowledge of subsequent postnatal respiratory function. We have determined the effectiveness of TO in fetal sheep with existing lung hypoplasia in restoring postnatal respiratory function. Lung hypoplasia was induced by lung liquid drainage from 112 days of gestation to term (~148 days). We used an untreated group (ULH), a treated group (TLH) in which the trachea was obstructed for 10 days, and a control group. ULH lambs died within 4 h of birth. TLH lambs were hypoxic for the first week and were hypercapic at 2 days. Pulmonary diffusing capacity, gas volumes, and respiratory compliances were not different between control and TLH lambs. Minute ventilation was not different between the two groups; however, tidal volumes were lower and respiratory frequencies were higher in TLH lambs than in controls for 2 wk after birth. We conclude that 10 days of TO in the presence of initial lung hypoplasia prevents death at birth and returns most aspects of pulmonary function to normal by 1-2 wk after birth.

fetus; newborn; lung function; fetal lung hypoplasia


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
O. Boucherat, A. Benachi, A.-M. Barlier-Mur, M.-L. Franco-Montoya, J. Martinovic, B. Thebaud, B. Chailley-Heu, and J. R. Bourbon
Decreased Lung Fibroblast Growth Factor 18 and Elastin in Human Congenital Diaphragmatic Hernia and Animal Models
Am. J. Respir. Crit. Care Med., May 15, 2007; 175(10): 1066 - 1077.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
R. Boland, B. J. Joyce, M. J. Wallace, H. Stanton, A. J. Fosang, R. A. Pierce, R. Harding, and S. B. Hooper
Cortisol enhances structural maturation of the hypoplastic fetal lung in sheep
J. Physiol., January 15, 2004; 554(2): 505 - 517.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Kitano, D. Von Allmen, M. Kanai, T. M. Quinn, P. Davies, Y. Kitano, and A. W. Flake
Fetal lung growth after short-term tracheal occlusion is linearly related to intratracheal pressure
J Appl Physiol, February 1, 2001; 90(2): 493 - 500.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online