Journal of Applied Physiology Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 87: 2253-2258, 1999;
8750-7587/99 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ceddia, M. A.
Right arrow Articles by Woods, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ceddia, M. A.
Right arrow Articles by Woods, J. A.
Vol. 87, Issue 6, 2253-2258, December 1999

Exercise suppresses macrophage antigen presentation

M. A. Ceddia and J. A. Woods

Physical Fitness Research Laboratory, Department of Kinesiology, University of Illinois, Urbana, Illinois 61801

This study determined the effects of exercise on the ability of macrophages (Mphi ) to present antigen to T cells. Pathogen-free male Balb/c mice (8 ± 2 wk of age) were randomly assigned to either home cage control, moderate exercise (Mod; 18 m/min, 5% grade, 0.5 h/day), exhaustive exercise (Exh, 18-30 m/min, 3 h/day), or treadmill control groups. The mice underwent treatments for 4 days during peritoneal thioglycolate inflammation. Peritoneal Mphi were harvested, purified, and incubated with chicken ovalbumin (C-OVA; 0-10 mg/ml) for 18 h. Mphi were then cocultured with C-OVA-specific T cells for 48 h, and the supernatants were analyzed via ELISA for interleukin-2 as an indication of Mphi antigen presentation (AP). Exh exhibited suppressed (~25-34%) Mphi AP across a wide range of C-OVA doses when measured immediately, 3, and 24 h postexercise. In contrast, Mod had reduced Mphi AP only at 3 h postexercise. Mphi AP was also lower in the treadmill control (4-27%) compared with the home cage control group, but was significantly higher than Exh. The reduction in Mphi AP was not due to exercise-induced differences in Mphi number, percentage, or expression of intercellular adhesion molecule-1, B7-2, or major histocompatability complex II, molecules important in AP. In conclusion, our data lend evidence that may help explain the increased incidence of infection observed after prolonged exhaustive exercise or overtraining.

immunity; stress; T lymphocytes; interleukin-2; mice; intercellular adhesion molecule-1


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. A. Murphy, J. M. Davis, A. S. Brown, M. D. Carmichael, J. A. Carson, N. Van Rooijen, A. Ghaffar, and E. P. Mayer
Benefits of oat {beta}-glucan on respiratory infection following exercise stress: role of lung macrophages
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1593 - R1599.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. L. Sherry, J. C. O'Connor, J. M. Kramer, and G. G. Freund
Augmented Lipopolysaccharide-Induced TNF-{alpha} Production by Peritoneal Macrophages in Type 2 Diabetic Mice Is Dependent on Elevated Glucose and Requires p38 MAPK
J. Immunol., January 15, 2007; 178(2): 663 - 670.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
A J McKune, L L Smith, S J Semple, and A A Wadee
Influence of ultra-endurance exercise on immunoglobulin isotypes and subclasses
Br. J. Sports Med., September 1, 2005; 39(9): 665 - 670.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. C. O'Connor, A. Satpathy, M. E. Hartman, E. M. Horvath, K. W. Kelley, R. Dantzer, R. W. Johnson, and G. G. Freund
IL-1{beta}-Mediated Innate Immunity Is Amplified in the db/db Mouse Model of Type 2 Diabetes
J. Immunol., April 15, 2005; 174(8): 4991 - 4997.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. A. Murphy, J. M. Davis, A. S. Brown, M. D. Carmichael, N. Van Rooijen, A. Ghaffar, and E. P. Mayer
Role of lung macrophages on susceptibility to respiratory infection following short-term moderate exercise training
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1354 - R1358.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. E. Hartman, J. C. O'Connor, J. P. Godbout, K. D. Minor, V. R. Mazzocco, and G. G. Freund
Insulin Receptor Substrate-2-dependent Interleukin-4 Signaling in Macrophages Is Impaired in Two Models of Type 2 Diabetes Mellitus
J. Biol. Chem., July 2, 2004; 279(27): 28045 - 28050.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. M. Davis, E. A. Murphy, A. S. Brown, M. D. Carmichael, A. Ghaffar, and E. P. Mayer
Effects of moderate exercise and oat {beta}-glucan on innate immune function and susceptibility to respiratory infection
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2004; 286(2): R366 - R372.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
G.-P. Shi, R. A.R. Bryant, R. Riese, S. Verhelst, C. Driessen, Z. Li, D. Bromme, H. L. Ploegh, and H. A. Chapman
Role for Cathepsin F in Invariant Chain Processing and Major Histocompatibility Complex Class II Peptide Loading by Macrophages
J. Exp. Med., April 3, 2000; 191(7): 1177 - 1186.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. A. Ceddia, E. W. Voss Jr., and J. A. Woods
Intracellular mechanisms responsible for exercise-induced suppression of macrophage antigen presentation
J Appl Physiol, February 1, 2000; 88(2): 804 - 810.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online