Journal of Applied Physiology
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J Appl Physiol 87: 2244-2252, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 6, 2244-2252, December 1999

Creatine supplementation increases muscle total creatine but not maximal intermittent exercise performance

Michael J. McKenna1, Judith Morton2, Steve E. Selig1, and Rodney J. Snow3

1 Department of Human Movement, Recreation, and Performance, Centre for Rehabilitation, Exercise, and Sports Science, Victoria University of Technology, Melbourne, Victoria 8001; 2 Department of Medicine, Monash Medical School, Alfred Hospital, Prahran, Victoria 3181; and 3 School of Human Movement, Deakin University, Burwood, Victoria 3125, Australia

This study investigated creatine supplementation (CrS) effects on muscle total creatine (TCr), creatine phosphate (CrP), and intermittent sprinting performance by using a design incorporating the time course of the initial increase and subsequent washout period of muscle TCr. Two groups of seven volunteers ingested either creatine [Cr; 6 × (5 g Cr-H2O + 5 g dextrose)/day)] or a placebo (6 × 5 g dextrose/day) over 5 days. Five 10-s maximal cycle ergometer sprints with rest intervals of 180, 50, 20, and 20 s and a resting vastus lateralis biopsy were conducted before and 0, 2, and 4 wk after placebo or CrS. Resting muscle TCr, CrP, and Cr were unchanged after the placebo but were increased (P < 0.05) at 0 [by 22.9 ± 4.2, 8.9 ± 1.9, and 14.0 ± 3.3 (SE) mmol/kg dry mass, respectively] and 2 but not 4 wk after CrS. An apparent placebo main effect of increased peak power and cumulative work was found after placebo and CrS, but no treatment (CrS) main effect was found on either variable. Thus, despite the rise and washout of muscle TCr and CrP, maximal intermittent sprinting performance was unchanged by CrS.

ergogenic aids; creatine washout; muscle performance; fatigue


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