Journal of Applied Physiology AJP: Heart and Circulatory Physiology
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J Appl Physiol 87: 2237-2243, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 6, 2237-2243, December 1999

Indomethacin does not influence natural cell-mediated cytotoxic response to endurance exercise

W. A. Braun1, M. G. Flynn2, D. E. Jacks3, T. McLoughlin3, J. Sowash3, C. P. Lambert3, and E. Mylona3

1 Human Performance Laboratory, California State Polytechnic University, Pomona, California 91768; 2 Wastl Human Performance Laboratory, Purdue University, West Lafayette, Indiana 47907; and 3 Exercise Physiology Laboratory, University of Toledo, Toledo, Ohio 43606

Natural cell-mediated cytotoxicity (NCMC) has been shown to be attenuated during recovery from high-intensity or prolonged exercise. Two theories have been proposed to explain the transient suppression of NCMC: prostaglandin-induced inhibition of natural killer (NK) cell activity or a numerical redistribution of NK cells. This study was designed to examine the effects of oral indomethacin (a prostaglandin inhibitor) on NCMC before and after 1 h of high-intensity running (85% maximal oxygen uptake). A secondary purpose was to compare whole blood and isolated peripheral blood mononuclear cell assay procedures for assessing NCMC. Ten male distance runners completed two trials that were preceded by either 48 h of indomethacin (Indo; 150 mg/day) or no treatment (control). NK (CD3-/CD16+/CD56+) cell concentrations were significantly elevated postexercise but were not affected by Indo. NCMC was significantly suppressed at 1.5 h of recovery relative to preexercise only with the whole blood assay procedure. Indo was not found to influence NCMC, leukocyte, or lymphocyte subset concentrations. Mean cytotoxic response was significantly greater with the whole blood method.

immune; natural killer cells; peripheral blood mononuclear cell; prostaglandin


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