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J Appl Physiol 87: 2168-2176, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 6, 2168-2176, December 1999

Influences of thigh cuffs on the cardiovascular system during 7-day head-down bed rest

P. Arbeille1, S. Herault1, G. Fomina2, J. Roumy1, I. Alferova2, and C. Gharib3

1 Unité Médecine et Physiologie Spatiale, Departement de Médecine Nucléaire et Ultrasons, Centres Hospitaliers Universitaires Trousseau, 37044 Tours, France; 2 Institute of Biomedical Problems, 123007 Moscow, Russia; and 3 Laboratoire Physiologie de l'Environnement, Faculté de Médecine Grange Blanche, 69373 Lyon, France

Thigh cuffs, presently named "bracelets," consist of two straps fixed to the upper part of each thigh, applying a pressure of 30 mmHg. The objective was to evaluate the cardiac, arterial, and venous changes in a group of subjects in head-down tilt (HDT) for 7 days by using thigh cuffs during the daytime, and in a control group not using cuffs. The cardiovascular parameters were measured by echography and Doppler. Seven days in HDT reduced stroke volume in both groups (-10%; P < 0.05). Lower limb vascular resistance decreased more in the cuff group than in the control group (-29 vs. -4%; P < 0.05). Cerebral resistance increased in the control group only (+6%; P < 0.05). The jugular vein increased (+45%; P < 0.05) and femoral and popliteal veins decreased in cross-sectional area in both groups (-45 and -8%, respectively; P < 0.05). Carotid diameter tended to decrease (-5%; not significant) in both groups. Heart rate, blood pressure, cardiac output, and total resistance did not change significantly. After 8 h with thigh cuffs, the cardiac and arterial parameters had recovered their pre-HDT level except for blood pressure (+6%; P < 0.05). Jugular vein size decreased from the pre-HDT level (-21%; P < 0.05), and femoral and popliteal vein size increased (+110 and +136%, respectively; P < 0.05). The thigh cuffs had no effect on the development of orthostatic intolerance during the 7 days in HDT.

microgravity; bracelets; orthostatic intolerance


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