Journal of Applied Physiology Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 87: 2073-2080, 1999;
8750-7587/99 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nodelman, V.
Right arrow Articles by Ultman, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nodelman, V.
Right arrow Articles by Ultman, J. S.
Vol. 87, Issue 6, 2073-2080, December 1999

Longitudinal distribution of chlorine absorption in human airways: a comparison to ozone absorption

Vladislav Nodelman and James S. Ultman

Biomolecular Transport Dynamics Laboratory, Department of Chemical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802

The bolus inhalation method was used to measure the fraction of inhaled chlorine (Cl2) and ozone (O3) absorbed during a single breath as a function of longitudinal position in the respiratory system of 10 healthy nonsmokers during oral and nasal breathing at respired flows of 150, 250, and 1,000 ml/s. At all experimental conditions, <5% of inspired Cl2 penetrated beyond the upper airways and none reached the respiratory air spaces. On the other hand, larger penetrations of O3 beyond the upper airways occurred as flow increased and during nasal than during oral breathing. In the extreme case of oral breathing at 1,000 ml/s, 35% of inhaled O3 penetrated beyond the upper airways and ~10% reached the respiratory air spaces. Mass transfer theory indicated that the diffusion resistance of the tissue phase was negligible for Cl2 but important for O3. The gas phase resistances were the same for Cl2 and O3 and were directly correlated with the volume of the nose and mouth during nasal and oral breathing, respectively.

air pollution; inhalation toxicology; lung dosimetry; mass transfer coefficient; regional uptake


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
J. G. Martin, H. R. Campbell, H. Iijima, D. Gautrin, J.-L. Malo, D. H. Eidelman, Q. Hamid, and K. Maghni
Chlorine-induced Injury to the Airways in Mice
Am. J. Respir. Crit. Care Med., September 1, 2003; 168(5): 568 - 574.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. Y. Santiago, M. C. Hann, A. Ben-Jebria, and J. S. Ultman
Ozone absorption in the human nose during unidirectional airflow
J Appl Physiol, August 1, 2001; 91(2): 725 - 732.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online