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J Appl Physiol 87: 2068-2072, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 6, 2068-2072, December 1999

Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by 1H-MRS

Jesús Rico-Sanz1, E. Louise Thomas1, Gabriele Jenkinson1, Sárka Mierisová2, Richard Iles1, and Jimmy D. Bell1

1 The Robert Steiner Magnetic Resonance Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 0HS, United Kingdom; and 2 Wihuri Research Institute, 00140 Helsinki, Finland

We used 1H-magnetic resonance spectroscopy to noninvasively determine total creatine (TCr), choline-containing compounds (Cho), and intracellular (IT) and extracellular (between-muscle fibers) triglycerides (ET) in three human skeletal muscles. Subjects' (n = 15 men) TCr concentrations in soleus [Sol; 100.2 ± 8.3 (SE) mmol/kg dry wt] were lower (P < 0.05) than those in gastrocnemius (Gast; 125.3 ± 9.2 mmol/kg dry wt) and tibialis anterior (TA; 123.7 ± 8.8 mmol/kg dry wt). The Cho levels in Sol (35.8 ± 3.6 mmol/kg dry wt) and Gast (28.5 ± 3.5 mmol/kg dry wt) were higher (P < 0.001 and P < 0.01, respectively) compared with TA (13.6 ± 2.4 mmol/kg dry wt). The IT values were found to be 44.8 ± 4.6 and 36.5 ± 4.2 mmol/kg dry wt in Sol and Gast, respectively. The IT values of TA (24.5 ± 4.5 mmol/kg dry wt) were lower than those of Sol (P < 0.01) and Gast (P < 0.05). There were no differences in ET [116.0 ± 11.2 (Sol), 119.1 ± 18.5 (Gast), and 91.4 ± 19.2 mmol/kg dry wt (TA)]. It is proposed that the differences in metabolite levels may be due to the differences in fiber-type composition and deposition of metabolites due to the adaptation of different muscles during locomotion.

free creatine; lipids; magnetic resonance spectroscopy; phosphocreatine


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