Journal of Applied Physiology
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J Appl Physiol 87: 2053-2058, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 6, 2053-2058, December 1999

Blood pressure and plasma catecholamines in acute and prolonged hypoxia: effects of local hypothermia

Inge-Lis Kanstrup1, Troels Dirch Poulsen2, Jesper Melchior Hansen1, Lars Juel Andersen3, Morten Heiberg Bestle4, Niels Juel Christensen5, and Niels Vidiendal Olsen6

Departments of 1 Clinical Physiology and Nuclear Medicine, 4 Anaesthesia and Intensive Care, and 5 Endocrinology, Herlev Hospital, 2 Department of Anaesthesia, Gentofte Hospital, 3 Institute of Medical Physiology, and 6 Institute of Pharmacology, University of Copenhagen, DK-2730 Herlev, Denmark

This study measured the pressor and plasma catecholamine response to local hypothermia during adaptation to hypobaric hypoxia. Eight healthy men were studied at rest and after 10 and 45 min of local cooling of one hand and forearm as well as after 30 min of rewarming at sea level and again 24 h and 5 days after rapid, passive transport to high altitude (4,559 m). Acute mountain sickness scores ranged from 5 to 16 (maximal attainable score: 20) on the first day but were reduced to 0-8 by the fifth day. Systolic blood pressure, heart rate, and plasma epinephrine increased on day 1 at altitude compared with sea level but declined again on day 5, whereas diastolic and mean blood pressures continued to rise in parallel with plasma norepinephrine. With local cooling, an increased vasoactive response was seen on the fifth day at altitude. Very high pressures were obtained, and the pressure elevation was prolonged. Heart rate increased twice as much on day 5 compared with the other two occasions. Thoracic fluid index increased with cooling on day 5, suggesting an increase in pulmonary vascular resistance. In conclusion, prolonged hypoxia seems to elicit an augmented pressor response to local cooling in the systemic and most likely also the pulmonary circulation.

acute mountain sickness; bioimpedance; healthy subjects; pulmonary vascular resistance; thoracic fluid index


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