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J Appl Physiol 87: 2043-2052, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 6, 2043-2052, December 1999

Analysis of intrapulmonary O2 concentration by MR imaging of inhaled hyperpolarized helium-3

B. Eberle1, N. Weiler1, K. Markstaller1,2, H.-U. Kauczor2, A. Deninger3, M. Ebert3, T. Grossmann3, W. Heil3, L. O. Lauer3, T. P. L. Roberts2, W. G. Schreiber2, R. Surkau3, W. F. Dick1, E. W. Otten3, and M. Thelen2

1 Department of Anesthesiology, 2 Department of Radiology, and 3 Institute of Physics, Johannes Gutenberg University, D-55131 Mainz, Germany

Inhalation of hyperpolarized 3He allows magnetic resonance imaging (MRI) of ventilated airspaces. 3He hyperpolarization decays more rapidly when interacting with paramagnetic O2. We describe a method for in vivo determination of intrapulmonary O2 concentrations ([O2]) based on MRI analysis of the fate of measured amounts of inhaled hyperpolarized 3He in imaged regions of the lung. Anesthetized pigs underwent controlled normoventilation in a 1.5-T MRI unit. The inspired O2 fraction was varied to achieve different end-tidal [O2] fractions (FETO2). With the use of a specifically designed applicator, 3He (100 ml, 35-45% polarized) was administered at a predefined time within single tidal volumes. During subsequent inspiratory apnea, serial two-dimensional images of airways and lungs were acquired. At least once in each animal studied, the radio-frequency excitation used for imaging was doubled at constant FETO2. Signal intensity measurements in regions of interest of the animals' lungs (volume range, 54-294 cm3), taken at two different radio-frequency excitations, permitted calculation of [O2] in these regions of interest. The [O2] fractions in the regions of interest correlated closely with FETO2 (R = 0.879; P < 0.0001). O2-sensitive 3He-MRI may allow noninvasive study of regional distribution of ventilation and alveolar PO2 in the lung.

lung; ventilation; distribution; respiratory gas; instrumentation; oxygen; measurement; noble gases


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