Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 87: 1724-1733, 1999;
8750-7587/99 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Freed, A. N.
Right arrow Articles by Suzuki, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Freed, A. N.
Right arrow Articles by Suzuki, R.
Vol. 87, Issue 5, 1724-1733, November 1999

Mucosal injury and eicosanoid kinetics during hyperventilation-induced bronchoconstriction

Arthur N. Freed, Yongqiang Wang, Sharron McCulloch, Teresa Myers, and Ryoichi Suzuki

Department of Environmental Health Sciences, The Johns Hopkins University, Baltimore, Maryland 21205

Bronchoalveolar lavage (BAL) of canine peripheral airways was performed at various times after hyperventilation, and BAL fluid (BALF) cell and mediator data were used to evaluate two hypotheses: 1) hyperventilation-induced mucosal injury stimulates mediator production, and 2) mucosal damage is correlated with the magnitude of hyperventilation-induced bronchoconstriction. We found that epithelial cells increased in BALF immediately after a 2- and a 5-min dry air challenge (DAC). Prostaglandins D2 and F2alpha and thromboxane B2 were unchanged immediately after a 2-min DAC but were significantly increased after a 5-min DAC. Leukotriene C4, D4, and E4 did not increase until 5 min after DAC. Hyperventilation with warm moist air did not alter BALF cells or mediators and caused less airway obstruction that occurred earlier than DAC. BALF epithelial cells were correlated with mediator release, and mediator release and epithelial cells were correlated with hyperventilation-induced bronchoconstriction. These observations are consistent with the hypothesis that hyperventilation-induced mucosal damage initiates peripheral airway constriction via the release of biochemical mediators.

airway resistance; exercise-induced asthma; leukotrienes; prostaglandins; thromboxane


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
T. S. Hallstrand, M. W. Moody, M. M. Wurfel, L. B. Schwartz, W. R. Henderson Jr., and M. L. Aitken
Inflammatory Basis of Exercise-induced Bronchoconstriction
Am. J. Respir. Crit. Care Med., September 15, 2005; 172(6): 679 - 686.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. N. Freed, S. McCulloch, T. Meyers, and R. Suzuki
Neurokinins Modulate Hyperventilation-induced Bronchoconstriction in Canine Peripheral Airways
Am. J. Respir. Crit. Care Med., April 15, 2003; 167(8): 1102 - 1108.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. SUZUKI and A. N. FREED
Heparin Inhibits Hyperventilation-Induced Late-Phase Hyperreactivity in Dogs
Am. J. Respir. Crit. Care Med., January 1, 2002; 165(1): 27 - 33.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. Suzuki and A. N. Freed
Hypertonic saline aerosol increases airway reactivity in the canine lung periphery
J Appl Physiol, December 1, 2000; 89(6): 2139 - 2146.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. N. Freed, S. McCulloch, and Y. Wang
Eicosanoid and muscarinic receptor blockade abolishes hyperventilation-induced bronchoconstriction
J Appl Physiol, November 1, 2000; 89(5): 1949 - 1955.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Wedde-Beer, C. Hu, M. M. Rodriguez, and G. Piedimonte
Leukotrienes mediate neurogenic inflammation in lungs of young rats infected with respiratory syncytial virus
Am J Physiol Lung Cell Mol Physiol, May 1, 2002; 282(5): L1143 - L1150.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online