Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol 87: 1684-1696, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 5, 1684-1696, November 1999

Active muscle and whole body lactate kinetics after endurance training in men

Bryan C. Bergman1, Eugene E. Wolfel2, Gail E. Butterfield3, Gary D. Lopaschuk4, Gretchen A. Casazza1, Michael A. Horning1, and George A. Brooks1

1 Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley 94720; 2 University of Colorado Health Sciences Center, Division of Cardiology, Denver, Colorado 80262; 3 Geriatric Research, Education, and Clinical Center, Palo Alto Veterans Affairs Health Care System, Palo Alto, California 95304; and 4 Departments of Pediatrics and Pharmacology, Cardiovascular Research Group, University of Alberta, Edmonton, Alberta, Canada T6G 2S2

We evaluated the hypotheses that endurance training decreases arterial lactate concentration ([lactate]a) during continuous exercise by decreasing net lactate release (L) and appearance rates (Ra) and increasing metabolic clearance rate (MCR). Measurements were made at two intensities before [45 and 65% peak O2 consumption (VO2 peak)] and after training [65% pretraining VO2 peak, same absolute workload (ABT), and 65% posttraining VO2 peak, same relative intensity (RLT)]. Nine men (27.4 ± 2.0 yr) trained for 9 wk on a cycle ergometer, 5 times/wk at 75% VO2 peak. Compared with the 65% VO2 peak pretraining condition (4.75 ± 0.4 mM), [lactate]a decreased at ABT (41%) and RLT (21%) (P < 0.05). L decreased at ABT but not at RLT. Leg lactate uptake and oxidation were unchanged at ABT but increased at RLT. MCR was unchanged at ABT but increased at RLT. We conclude that 1) active skeletal muscle is not solely responsible for elevated [lactate]a; and 2) training increases leg lactate clearance, decreases whole body and leg lactate production at a given moderate-intensity power output, and increases both whole body and leg lactate clearance at a high relative power output.

lactate shuttle; exertion; glycogen; glucose; stable isotopes


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