| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Ritchie Centre for Baby Health Research, Institute of Reproduction and Development, Monash University, Clayton, Victoria 3168, Australia; and 2 Department of Physiology/Biophysics, Faculty of Medicine, The University of Calgary, Calgary, Alberta, Canada T2N 4N1
A midsystolic plateau differentiates the pattern
of fetal pulmonary trunk blood flow from aortic flow. To determine
whether this plateau arises from interactions between the left (LV) and right ventricle (RV) via the ductus arteriosus or from interactions between the RV and the lung vasculature, we measured blood flows and
pressures in the pulmonary trunk and aorta of eight anesthetized (ketamine and 
-chloralose) fetal lambs. Wave-intensity analysis revealed waves of energy traveling forward, away from the LV and the RV
early in systole. During midsystole, a wave of energy traveling back
toward the RV decreased blood flow velocity from the RV and produced
the plateau in blood flow. Calculations revealed that this
backward-traveling wave originated as a forward-traveling wave
generated by the RV that was reflected from the lung vasculature back
toward the heart and not as a forward-traveling wave generated by the
LV that crossed the ductus arteriosus. Elimination of this backward-traveling wave and its associated effect on RV flow may be an
important component of the increase in RV output that accompanies birth.
wave-intensity analysis; left ventricle; heart-lung interactions
This article has been cited by other articles:
|
|
 |
|
  J. J. Smolich, J. P. Mynard, and D. J. Penny Simultaneous pulmonary trunk and pulmonary arterial wave intensity analysis in fetal lambs: evidence for cyclical, midsystolic pulmonary vasoconstriction Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1554 - R1562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Groves, C. A. Kuschel, and J. R. Skinner International Perspectives: The Neonatologist as an Echocardiographer NeoReviews, August 1, 2006; 7(8): e391 - e399. [Full Text] [PDF]
|
|
|
|
 |
|
 G. R. Polglase, M. J. Wallace, D. L. Morgan, and S. B. Hooper Increases in lung expansion alter pulmonary hemodynamics in fetal sheep J Appl Physiol, July 1, 2006; 101(1): 273 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. R. Polglase, C. J. Morley, K. J. Crossley, P. Dargaville, R. Harding, D. L. Morgan, and S. B. Hooper Positive end-expiratory pressure differentially alters pulmonary hemodynamics and oxygenation in ventilated, very premature lambs J Appl Physiol, October 1, 2005; 99(4): 1453 - 1461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. H. Hollander, G. M. Dobson, J.-J. Wang, K. H. Parker, and J. V. Tyberg Direct and series transmission of left atrial pressure perturbations to the pulmonary artery: a study using wave-intensity analysis Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H267 - H275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-J. Wang, A. B. O'Brien, N. G. Shrive, K. H. Parker, and J. V. Tyberg Time-domain representation of ventricular-arterial coupling as a windkessel and wave system Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1358 - H1368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Sun, T. J. Anderson, K. H. Parker, and J. V. Tyberg Wave-intensity analysis: a new approach to coronary hemodynamics J Appl Physiol, October 1, 2000; 89(4): 1636 - 1644. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
