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J Appl Physiol 87: 1609-1613, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 5, 1609-1613, November 1999

Direct cooling of the human brain by heat loss from the upper respiratory tract

Zenon Mariak1, Matthew D. White2, Janusz Lewko1, T. Lyson1, and P. Piekarski1

1 Department of Neurosurgery, University Medical School, 15-276 Bialystok, Poland; and 2 School of Physical Education, Recreation and Athletics, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1C 5S7

This study is the first report on human intracranial temperature in conscious patients during and after an upper respiratory bypass. Temperatures were measured in four subjects subdurally between the frontal lobes and cribriform plate (Tcr) and on the vault of the skull (Tsd). Further measurements were taken in the esophagus (Tes) and on the tympanic membrane. Reinstitution of airflow in the upper respiratory tract under conditions of mild hyperthermia gave a rapid drop in Tcr of 0.4-0.8°C. In three patients the intracranial temperature at the basal aspect of the frontal lobes fell below Tes. Thus local selective cooling of the brain surface below that of the trunk temperature was shown to occur. Intensive breathing by the patients after extubation for a 3-min period produced a cooling at the site of Tcr measurement at a rate of up to 0.1°C/min, and this response could be evoked on demand. The results support the view that cooling of the upper airway can directly influence human brain temperature.

brain temperature; respiratory heat loss; selective brain cooling; human


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