Journal of Applied Physiology
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J Appl Physiol 87: 1567-1583, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 5, 1567-1583, November 1999

INVITED REVIEW
An alternative view of the role(s) of surfactant and the alveolar model

Brian A. Hills

Paediatric Respiratory Research Centre, Mater Children's Hospital, and Department of Medicine, The University of Queensland, Brisbane, Queensland 4101, Australia

Currently, the study of surfactant proteins is much in vogue, but, in the early days, the physics underlying surfactant function was treated somewhat superficially, leaving assumptions that have become culturally embedded, such as the "bubble" model of the alveolus. This review selectively reexamines these assumptions, comparing each combination of alveolar model and role of surfactant for compatibility with the major features of pulmonary mechanics and alveolar stability, morphology, and fluid balance.

alveolar edema; alveolar fluid balance; alveolar models; pulmonary mechanics


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