Journal of Applied Physiology
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J Appl Physiol 87: 1546-1554, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 4, 1546-1554, October 1999

SPECIAL COMMUNICATION
Interrupter airway and tissue resistance: errors caused by valve properties and respiratory system compliance

Volker Kessler1, Georg Mols1, Holger Bernhard1, Christoph Haberthür2, and Josef Guttmann1

1 Section of Experimental Anesthesiology, Department of Anesthesiology and Critical Care Medicine, University of Freiburg, 79106 Freiburg, Germany; and 2 Division of Clinical Physiology, Clinic of Cardiac and Thoracic Surgery, University Hospital, 4031 Basel, Switzerland

The interrupter technique is used to determine airway and tissue resistance. Their accuracy is influenced by the technical properties of the interrupter device and the compliance of the respiratory system. We investigated the influence of valve characteristics and respiratory system compliance on the accuracy of determining airway and tissue resistance by means of a computer simulation. With decreasing compliance we found increasing errors in both airway and tissue resistance determination of up to 34 and 71%, respectively. On this basis we developed a new occlusion valve, with special emphasis on rapid closing time and tightness in the closed state to improve the accuracy of resistance determination. The newly developed occlusion device greatly improves the accuracy of airway and tissue resistance determination. We conclude that respiratory system compliance is a limiting factor for the accuracy of the interrupter technique. To apply the interrupter technique in patients with extremely low respiratory system compliances, we need sophisticated technical devices.

computer simulation; initial pressure drop; interrupter technique; respiratory system mechanics


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