Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol 87: 1506-1512, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 4, 1506-1512, October 1999

INVITED REVIEW
Measurement of cardiac output during exercise by open-circuit acetylene uptake

Rebecca C. Barker1, Susan R. Hopkins1, Nancy Kellogg1, I. Mark Olfert1, Tom D. Brutsaert1, Timothy P. Gavin1, Pauline L. Entin1, Anthony J. Rice2, and Peter D. Wagner1

1 Department of Medicine, University of California, San Diego, La Jolla, California 92093; and 2 Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia

Noninvasive measurement of cardiac output (QT) is problematic during heavy exercise. We report a new approach that avoids unpleasant rebreathing and resultant changes in alveolar PO2 or PCO2 by measuring short-term acetylene (C2H2) uptake by an open-circuit technique, with application of mass balance for the calculation of QT. The method assumes that alveolar and arterial C2H2 pressures are the same, and we account for C2H2 recirculation by extrapolating end-tidal C2H2 back to breath 1 of the maneuver. We correct for incomplete gas mixing by using He in the inspired mixture. The maneuver involves switching the subject to air containing trace amounts of C2H2 and He; ventilation and pressures of He, C2H2, and CO2 are measured continuously (the latter by mass spectrometer) for 20-25 breaths. Data from three subjects for whom multiple Fick O2 measurements of QT were available showed that measurement of QT by the Fick method and by the C2H2 technique was statistically similar from rest to 90% of maximal O2 consumption (VO2 max). Data from 12 active women and 12 elite male athletes at rest and 90% of VO2 max fell on a single linear relationship, with O2 consumption (VO2) predicting QT values of 9.13, 15.9, 22.6, and 29.4 l/min at VO2 of 1, 2, 3, and 4 l/min. Mixed venous PO2 predicted from C2H2-determined QT, measured VO2, and arterial O2 concentration was ~20-25 Torr at 90% of VO2 max during air breathing and 10-15 Torr during 13% O2 breathing. This modification of previous gas uptake methods, to avoid rebreathing, produces reasonable data from rest to heavy exercise in normal subjects.

maximal exercise; new methodology; inert gas


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