| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland 21287-2533
The response to inspiratory resistance loading
(IRL) of the upper airway during sleep in children is not
known. We, therefore, evaluated the arousal responses to
IRL during sleep in children with the obstructive sleep apnea syndrome
(OSAS) compared with controls. Children with OSAS aroused at a higher
load than did controls (23 ± 8 vs. 15 ± 7 cmH2O · l
1 · s;
P < 0.05). Patients with OSAS had
higher arousal thresholds during rapid eye movement (REM) vs. non-REM
sleep (P < 0.001), whereas normal
subjects had lower arousal thresholds during REM (P < 0.005). Ventilatory responses
to IRL were evaluated in the controls. There was a marked decrease in
tidal volume both immediately (56 ± 17% of baseline at
an IRL of 15 cmH2O · l1 · min;
P < 0.001) and after 3 min of IRL
(67 ± 23%, P < 0.005). The duty
cycle increased. We conclude that children with OSAS have impaired
arousal responses to IRL. Despite compensatory changes in respiratory
timing, normal children have a decrease in minute ventilation in
response to IRL during sleep. However, arousal occurs before
gas-exchange abnormalities.
arousal; ventilatory drive; sleep-disordered breathing
This article has been cited by other articles:
|
|
 |
|
  E. S. Katz and C. M. D'Ambrosio Pathophysiology of Pediatric Obstructive Sleep Apnea Proceedings of the ATS, February 15, 2008; 5(2): 253 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Marcus Pediatric Sleep Medicine Comes Into Its Own Pediatrics, May 1, 2004; 113(5): 1393 - 1394. [Full Text] [PDF]
|
|
|
|
 |
|
 E. Durand, F. Lofaso, S. Dauger, G. Vardon, C. Gaultier, and J. Gallego Intermittent hypoxia induces transient arousal delay in newborn mice J Appl Physiol, March 1, 2004; 96(3): 1216 - 1222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Pagani, M. P. Villa, G. Calcagnini, A. Alterio, R. Ambrosio, F. Censi, and R. Ronchetti Pulse Transit Time as a Measure of Inspiratory Effort in Children Chest, October 1, 2003; 124(4): 1487 - 1493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Harrington, T. Kirjavainen, A. Teng, and C. E. Sullivan nCPAP improves abnormal autonomic function in at-risk-for-SIDS infants with OSA J Appl Physiol, October 1, 2003; 95(4): 1591 - 1597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. MARCUS Sleep-disordered Breathing in Children Am. J. Respir. Crit. Care Med., July 1, 2001; 164(1): 16 - 30. [Full Text] [PDF]
|
|
|
|
|
|
G. W. Don, T. Kirjavainen, C. Broome, C. Seton, and K. A. Waters Site and mechanics of spontaneous, sleep-associated obstructive apnea in infants J Appl Physiol, December 1, 2000; 89(6): 2453 - 2462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Y. T. GOH, P. GALSTER, and C. L. MARCUS Sleep Architecture and Respiratory Disturbances in Children with Obstructive Sleep Apnea Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): 682 - 686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Waters, F. McBrien, P. Stewart, M. Hinder, and S. Wharton Effects of OSA, inhalational anesthesia, and fentanyl on the airway and ventilation of children J Appl Physiol, May 1, 2002; 92(5): 1987 - 1994. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
