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1 Division of Respiratory Medicine, 2 Department of Pediatrics, and 3 Department of Biochemistry, McGill University Health Centre-Montreal Children's Hospital, Montreal, Quebec, Canada H3H 1P3
Oxidative stress contributes to muscular
fatigue. GSH is the major intracellular antioxidant, the biosynthesis
of which is dependent on cysteine availability. We hypothesized that
supplementation with a whey-based cysteine donor [Immunocal
(HMS90)] designed to augment intracellular GSH would enhance
performance. Twenty healthy young adults (10 men, 10 women) were
studied presupplementation and 3 mo postsupplementation with either
Immunocal (20 g/day) or casein placebo. Muscular performance was
assessed by whole leg isokinetic cycle testing, measuring peak power
and 30-s work capacity. Lymphocyte GSH was used as a marker of tissue
GSH. There were no baseline differences (age, ht, wt, %ideal wt, peak
power, 30-s work capacity). Follow-up data on 18 subjects (9 Immunocal, 9 placebo) were analyzed. Both peak power [13 ± 3.5 (SE) %,
P < 0.02] and 30-s work
capacity (13 ± 3.7%, P < 0.03)
increased significantly in the Immunocal group, with no change (2 ± 9.0 and 1 ± 9.3%) in the placebo group. Lymphocyte GSH also
increased significantly in the Immunocal group (35.5 ± 11.04%,
P < 0.02), with no change in the
placebo group (
0.9 ± 9.6%). This is the first study to
demonstrate that prolonged supplementation with a product designed to
augment antioxidant defenses resulted in improved volitional performance.
oxidative stress; exercise
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