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J Appl Physiol 87: 1373-1380, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 4, 1373-1380, October 1999

INVITED REVIEW
Effects of salbutamol and Ro-20-1724 on airway and parenchymal mechanics in rats

Ferenc Peták1,2, Janet L. Wale1, and Peter D. Sly1

1 Division of Clinical Sciences, Institute for Child Health Research, Perth, Western Australia 6001; and 2 Department of Medical Informatics and Engineering, Albert Szent-Györgyi Medical University, H-6701 Szeged, Hungary

We investigated the effects of a selective beta 2-agonist, salbutamol, and of phosphodiesterase type 4 inhibition with 4-(3-butoxy-4-methoxy benzyl)-2-imidazolidinone (Ro-20-1724) on the airway and parenchymal mechanics during steady-state constriction induced by MCh administered as an aerosol or intravenously (iv). The wave-tube technique was used to measure the lung input impedance (ZL) between 0.5 and 20 Hz in 31 anesthetized, paralyzed, open-chest adult Brown Norway rats. To separate the airway and parenchymal responses, a model containing an airway resistance (Raw) and inertance (Iaw), and a parenchymal damping (G) and elastance (H), was fitted to ZL spectra under control conditions, during steady-state constriction, and after either salbutamol or Ro-20-1724 delivery. In the Brown Norway rat, the response to iv MCh infusion was seen in Raw and G, whereas continuous aerosolized MCh challenge produced increases in G and H only. Both salbutamol, administered either as an aerosol or iv, and Ro-20-1724 significantly reversed the increases in Raw and G when MCh was administered iv. During the MCh aerosol challenge, Ro-20-1724 significantly reversed the increases in G and H, whereas salbutamol had no effect. These results suggest that, after MCh-induced changes in lung function, salbutamol increases the airway caliber. Ro-20-1724 is effective in reversing the airway narrowings, and it may also decrease the parenchymal constriction.

forced oscillation; airway resistance; tissue resistance; bronchodilators


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