| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Centre for Cardiovascular
Genetics,
Human physical performance is strongly
influenced by genetic factors. A variation in the
structure of the human angiotensin I-converting enzyme (ACE) gene has
been reported in which the insertion (I) variant is associated with
lower ACE levels than the deletion (D) gene. We have previously
reported that the I variant was associated with improved endurance
performance in high-altitude mountaineers and British Army recruits. We
now examine this genotype distribution in 91 British Olympic-standard
runners (79 Caucasians). DNA was extracted from the buccal cells
contained in 10 ml of saline mouthwash donated by the subjects, and the I and D variants of the ACE gene were identified by PCR amplification of the polymorphic region. There was an increasing frequency of the I
allele with distance run [0.35, 0.53, and 0.62 for 
200 m
(n = 20), 400-3,000 m
(n = 37), and 
5,000 m
(n = 34), respectively; P = 0.009 for linear trend].
Among 404 Olympic-standard athletes from 19 other mixed sporting
disciplines (in which endurance performance was not necessarily a key
factor), the I allele did not differ significantly from that found in
control subjects: 0.50 vs. 0.49 (P = 0.526). These results support a positive association of the I allele
with elite endurance performance.
exercise; angiontensin I-converting enzyme genotype; polymorphism
This article has been cited by other articles:
|
|
 |
|
  B. D. Levine : what do we know, and what do we still need to know? J. Physiol., January 1, 2008; 586(1): 25 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Yamin, O. Amir, M. Sagiv, E. Attias, Y. Meckel, N. Eynon, M. Sagiv, and R. E. Amir ACE ID genotype affects blood creatine kinase response to eccentric exercise J Appl Physiol, December 1, 2007; 103(6): 2057 - 2061. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Amir, R. Amir, C. Yamin, E. Attias, N. Eynon, M. Sagiv, M. Sagiv, and Y. Meckel Human, Environmental & Exercise: The ACE deletion allele is associated with Israeli elite endurance athletes Exp Physiol, September 1, 2007; 92(5): 881 - 886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Heled, M. S. Bloom, T. J. Wu, Q. Stephens, and P. A. Deuster CM-MM and ACE genotypes and physiological prediction of the creatine kinase response to exercise J Appl Physiol, August 1, 2007; 103(2): 504 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. S. Evangelista and J. E. Krieger Small gene effect and exercise training-induced cardiac hypertrophy in mice: an Ace gene dosage study Physiol Genomics, November 21, 2006; 27(3): 231 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.A. Sayed-Tabatabaei, B.A. Oostra, A. Isaacs, C.M. van Duijn, and J.C.M. Witteman ACE Polymorphisms Circ. Res., May 12, 2006; 98(9): 1123 - 1133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S Hopkinson, K. I Eleftheriou, J. Payne, A. H Nickol, E. Hawe, J. Moxham, H. Montgomery, and M. I Polkey +9/+9 Homozygosity of the bradykinin receptor gene polymorphism is associated with reduced fat-free mass in chronic obstructive pulmonary disease. Am. J. Clinical Nutrition, April 1, 2006; 83(4): 912 - 917. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. R Thompson and S. A Binder-Macleod Association of Genetic Factors With Selected Measures of Physical Performance Physical Therapy, April 1, 2006; 86(4): 585 - 591. [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Saunders, S. L. Xenophontos, M. A. Cariolou, L. C. Anastassiades, T. D. Noakes, and M. Collins The bradykinin {beta}2 receptor (BDKRB2) and endothelial nitric oxide synthase 3 (NOS3) genes and endurance performance during Ironman Triathlons Hum. Mol. Genet., March 15, 2006; 15(6): 979 - 987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B Walpole, T D Noakes, M Collins, and R J Trent Growth hormone 1 (GH1) gene and performance and post-race rectal temperature during the South African Ironman triathlon * Commentary Br. J. Sports Med., February 1, 2006; 40(2): 145 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Carter, G. Onder, S. B. Kritchevsky, and M. Pahor Angiotensin-Converting Enzyme Inhibition Intervention in Elderly Persons: Effects on Body Composition and Physical Performance J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2005; 60(11): 1437 - 1446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Kritchevsky, B. J. Nicklas, M. Visser, E. M. Simonsick, A. B. Newman, T. B. Harris, E. M. Lange, B. W. Penninx, B. H. Goodpaster, S. Satterfield, et al. Angiotensin-Converting Enzyme Insertion/Deletion Genotype, Exercise, and Physical Decline JAMA, August 10, 2005; 294(6): 691 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Grigorenko The Inherent Complexities of Gene-Environment Interactions J. Gerontol. B. Psychol. Sci. Soc. Sci., March 1, 2005; 60(suppl_Special_Issue_1): 53 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S. Hopkinson, A. H. Nickol, J. Payne, E. Hawe, W. D.-C. Man, J. Moxham, H. Montgomery, and M. I. Polkey ACE Gene Polymorphism in COPD Am. J. Respir. Crit. Care Med., September 1, 2004; 170(5): 572 - 573. [Full Text]
|
|
|
|
|
|
Y. Heled, D. S. Moran, L. Mendel, A. Laor, E. Pras, and Y. Shapiro Human ACE I/D polymorphism is associated with individual differences in exercise heat tolerance J Appl Physiol, July 1, 2004; 97(1): 72 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Williams, S. S. Dhamrait, P. T. E. Wootton, S. H. Day, E. Hawe, J. R. Payne, S. G. Myerson, M. World, R. Budgett, S. E. Humphries, et al. Bradykinin receptor gene variant and human physical performance J Appl Physiol, March 1, 2004; 96(3): 938 - 942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Bahi, N. Koulmann, H. Sanchez, I. Momken, V. Veksler, A. X. Bigard, and R. Ventura-Clapier Does ACE inhibition enhance endurance performance and muscle energy metabolism in rats? J Appl Physiol, January 1, 2004; 96(1): 59 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Patel, D.R. Woods, N.J. Macleod, A. Brown, K.R. Patel, H.E. Montgomery, and A.J. Peacock Angiotensin-converting enzyme genotype and the ventilatory responseto exertional hypoxia Eur. Respir. J., November 1, 2003; 22(5): 755 - 760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Hernandez, A. de la Rosa, A. Barragan, Y. Barrios, E. Salido, A. Torres, B. Martin, I. Laynez, A. Duque, A. De Vera, et al. The ACE/DD genotype is associated with the extent of exercise-induced left ventricular growth in endurance athletes J. Am. Coll. Cardiol., August 6, 2003; 42(3): 527 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Aldashev, A. S. Sarybaev, A. S. Sydykov, B. B. Kalmyrzaev, E. V. Kim, L. B. Mamanova, R. Maripov, B. K. Kojonazarov, M. M. Mirrakhimov, M. R. Wilkins, et al. Characterization of High-Altitude Pulmonary Hypertension in the Kyrgyz: Association with Angiotensin-Converting Enzyme Genotype Am. J. Respir. Crit. Care Med., November 15, 2002; 166(10): 1396 - 1402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Williams, S. H. Day, S. Dhamrait ;, and R. M. Fuentes ACE gene, physical activity, and physical fitness J Appl Physiol, October 1, 2002; 93(4): 1561 - 1562. [Full Text] [PDF]
|
|
|
|
|
|
D. R. Woods, A. J. Pollard, D. J. Collier, Y. Jamshidi, V. Vassiliou, E. Hawe, S. E. Humphries, and H. E. Montgomery Insertion/Deletion Polymorphism of the Angiotensin I-Converting Enzyme Gene and Arterial Oxygen Saturation at High Altitude Am. J. Respir. Crit. Care Med., August 1, 2002; 166(3): 362 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Fuentes, M. Perola, A. Nissinen, and J. Tuomilehto ACE gene and physical activity, blood pressure, and hypertension: a population study in Finland J Appl Physiol, June 1, 2002; 92(6): 2508 - 2512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Sonna, M. A. Sharp, J. J. Knapik, M. Cullivan, K. C. Angel, J. F. Patton, and C. M. Lilly Angiotensin-converting enzyme genotype and physical performance during US Army basic training J Appl Physiol, September 1, 2001; 91(3): 1355 - 1363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Rankinen, B. Wolfarth, J.-A. Simoneau, D. Maier-Lenz, R. Rauramaa, M. A. Rivera, M. R. Boulay, Y. C. Chagnon, L. Perusse, J. Keul, et al. No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status J Appl Physiol, May 1, 2000; 88(5): 1571 - 1575. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
