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J Appl Physiol 87: 1296-1300, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 4, 1296-1300, October 1999

INVITED REVIEW
Acetylcholine chloride and renal hemodynamics during postnatal maturation in conscious lambs

Alp Sener and Francine G. Smith

Departments of Physiology and Biophysics and of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1

To test the hypothesis that acetylcholine-induced relaxation of the renal artery decreases with postnatal age, we measured parameters of renal hemodynamics before and for 35 s after aortic suprarenal injection of acetylcholine in conscious, chronically instrumented lambs aged ~1 wk (n = 5) and ~6 wk (n = 5). Acetylcholine was administered in one of five doses ranging from 0 to 10 mg/kg body wt; doses were administered randomly, in the same volume. There were significant age- and dose-dependent changes in renal vascular resistance after acetylcholine administration, such that the response was greater in 1-wk-old lambs. After the highest dose tested, renal vascular resistance decreased by 13.6 ± 7.3 (SD) mmHg · ml-1 · min · g kidney wt in 1-wk-old lambs and by 9.1 ± 3.2 mmHg · ml-1 · min · g kidney wt in 6-wk-old lambs at 35 s. We also observed a transient renal vasoconstriction before the renal vasodilatation in 6-wk-old lambs but not in 1-wk-old animals. These data provide the first age- and dose-dependent effects of exogenous administration of acetylcholine on renal hemodynamics during maturation in conscious animals.

renal vascular resistance; endothelium; nitric oxide; kidney; perinatal


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