Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 87: 1260-1265, 1999;
8750-7587/99 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Holden, W. E.
Right arrow Articles by Giraud, G. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holden, W. E.
Right arrow Articles by Giraud, G. D.
Vol. 87, Issue 4, 1260-1265, October 1999

INVITED REVIEW
Temperature conditioning of nasal air: effects of vasoactive agents and involvement of nitric oxide

William E. Holden1, John P. Wilkins1, Michelle Harris1, Henry A. Milczuk2, and George D. Giraud1

1 Medical Service, Portland Veterans Affairs Medical Center, and 2 Department of Otolaryngology, Oregon Health Sciences University, Portland, Oregon 97201

Nitric oxide (NO) is released into nasal air, but its function is unknown. We hypothesized that nasal vascular tone and/or flow influences temperature conditioning of nasal air and that NO participates in this process. We measured nasal air temperature (via a thermocouple) and exhaled nasal NO release (by chemiluminescence) in five humans and examined the effects of an aerosolized vasoconstrictor (oxymetazoline), a vasodilator (papaverine), NG-nitro-L-arginine methyl ester, an inhibitor of NO synthase, or saline (control). Compared with saline (which caused no changes in nasal air temperature or exhaled NO release), oxymetazoline (0.05%) reduced nasal air temperature and NO release (130.8 ± 15.1 to 81.3 ± 12.8 nl · min-1 · m-2; P < 0.01). Papaverine (0.01 M) increased nasal air temperature and NO release (131.8 ± 13.1 to 157.2 ± 17.4 nl · min-1 · m-2; P < 0.03). NG-nitro-L-arginine methyl ester reduced nasal air temperature and NO release (123.7 ± 14.2 to 44.2 ± 23.7 nl · min-1 · m-2; P < 0.01). The results suggest that vascular tone and/or flow modulates temperature conditioning and that NO may participate in that function.

temperature regulation; nose; vasoconstrictor; vasodilator


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. Kotaru, R. B. Hejal, J. H. Finigan, A. J. Coreno, M. E. Skowronski, L. J. Brianas, and E. R. McFadden Jr.
Influence of hyperpnea on airway surface fluid volume and osmolarity in normal humans
J Appl Physiol, July 1, 2002; 93(1): 154 - 160.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Kotaru, M. Skowronski, A. Coreno, and E. R. McFadden Jr.
Inhibition of nitric oxide synthesis attenuates thermally induced asthma
J Appl Physiol, August 1, 2001; 91(2): 703 - 708.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. A. KHARITONOV and P. J. BARNES
Exhaled Markers of Pulmonary Disease
Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1693 - 1722.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. KOTARU, A. CORENO, M. SKOWRONSKI, R. CIUFO, and E. R. MCFADDEN Jr.
Exhaled Nitric Oxide and Thermally Induced Asthma
Am. J. Respir. Crit. Care Med., February 1, 2001; 163(2): 383 - 388.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online