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1-adrenoceptor agonist in in
vivo studies on human thermogenesis and lipid utilization
Nutrition Toxicology and Environment Research Institute Maastricht, Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands
The use of dobutamine as selective
1-adrenoceptor agonist in in
vivo studies on human thermogenesis and lipid utilization was
investigated in 20 men. At 2.5, 5, and 10 µg · kg
1 · min1,
dobutamine induced significant increases in energy expenditure, lipid
oxidation, and lipolysis. The
1-adrenoceptor antagonist atenolol (bolus: 42.5 µg/kg, infusion: 1.02 µg · kg1 · min1)
blocked all dobutamine-induced effects on thermogenesis and lipid
utilization. All parameters remained at levels comparable to those
during saline infusion. The dose of atenolol used did not inhibit
2-adrenoceptor-specific changes
in energy expenditure, lipid oxidation, and lipolysis during salbutamol
infusion (85 ng · kg1 · min1).
This indicates that atenolol was specific for
1-adrenoceptors and did not
camouflage concomitant
2-adrenoceptor stimulation during dobutamine infusion. Therefore, we conclude that dobutamine can
be used as a selective
1-adrenoceptor agonist at
dosages 
10
µg · kg1 · min1
in in vivo studies on human thermogenesis and lipid utilization.
atenolol; salbutamol; lipid oxidation; lipolysis
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