Journal of Applied Physiology
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J Appl Physiol 87: 1172-1177, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 3, 1172-1177, September 1999

Endothelin-1 sensitivity of porcine coronary arteries is reduced by exercise training and is gender dependent

Allan W. Jones, Leona J. Rubin, and Lawrence Magliola

Departments of Physiology and Veterinary Biomedical Sciences and Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, Missouri 65212

We tested the hypothesis that exercise training reduces the sensitivity of coronary smooth muscle to endothelin-1 (ET-1), with the adaptation being greater in male than in female miniature swine. The efficacy of training was similar in males and females. Cumulative ET-1 contractile responses of coronary branches and left circumflex artery were significantly shifted to the right in exercise-trained (Ex) males but not in Ex females. Analyses of the excitatory concentration causing a 50% response (EC50) showed a 1.7- to 2.2-fold shift in Ex males with no change in maximum tension. Nonselective blockade of K-channel activity with tetraethylammonium (TEA; 30-50 mM) significantly shifted the EC50 to a lower concentration in both Ex males (1.25-fold) and Ex females (2.2-fold) but not in sedentary (Sed) groups. Females (combined Sed and Ex) exhibited a greater response to TEA than did combined Sed and Ex males. Changes in [32P]phosphatidic acid ([32P]PA) provided an indicator of ET-1-induced phospholipase activity. The magnitude of the [32P]PA response was reduced by Ex in both males and females without affecting the EC50. It is concluded that the contractile sensitivity of coronary arteries to ET-1 is influenced by physical activity in a gender-dependent manner. It is unclear why the contractile sensitivity in females was not reduced by Ex as in the males, because Ex significantly affected responses to TEA and ET-1 stimulation of [32P]PA production in both males and females. A potential gender difference in K-channel function may contribute to this discrepancy.

potassium channels; contraction; phospholipase activity; phosphatidic acid; heart weight; oxidative capacity; endurance time; miniature swine


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