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1 Department of Medicine, and 2 Department of Human Services, University of Virginia, Charlottesville, Virginia 22903
We examined gender differences in growth hormone
(GH) secretion during rest and exercise. Eighteen subjects (9 women and
9 men) were tested on two occasions each [resting condition (R) and exercise condition (Ex)]. Blood was sampled at 10-min
intervals from 0600 to 1200 and was assayed for GH by
chemiluminescence. At R, women had a 3.69-fold greater mean calculated
mass of GH secreted per burst compared with men (5.4 ± 1.0 vs. 1.7 ± 0.4 µg/l, respectively) and higher basal (interpulse) GH
secretion rates, which resulted in greater GH production rates and
serum GH area under the curve (AUC; 1,107 ± 194 vs. 595 ± 146 µg · l
1 · min,
women vs. men; P = 0.04).
Compared with R, Ex resulted in greater mean mass of GH secreted per
burst, greater mean GH secretory burst amplitude, and greater GH AUC
(1,196 ± 211 vs. 506 ± 90 µg · l1 · min,
Ex vs. R, respectivley; P < 0.001).
During Ex, women attained maximal serum GH concentrations significantly
earlier than men (24 vs. 32 min after initiation of Ex, respectively;
P = 0.004). Despite this temporal
disparity, both genders had similar maximal serum GH concentrations.
The change in AUC (adjusted for unequal baselines) was similar for men
and women (593 ± 201 vs. 811 ± 268 µg · l1 · min),
but there were significant gender-by-condition interactive effects on
GH secretory burst mass, pulsatile GH production rate, and maximal
serum GH concentration. We conclude that, although women exhibit
greater absolute GH secretion rates than men both at rest and during
exercise, exercise evokes a similar incremental GH response in men and
women. Thus the magnitude of the incremental secretory GH response is
not gender dependent.
sex steroids; deconvolution analysis; endocrinology; human
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