Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol 87: 1066-1074, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 3, 1066-1074, September 1999

Rhythmic sympathetic nerve discharges in an in vitro neonatal rat brain stem-spinal cord preparation

Chun-Kuei Su

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan 11529, Republic of China

To understand the origination of sympathetic nerve discharge (SND), I developed an in vitro brain stem-spinal cord preparation from neonatal rats. Ascorbic acid (3 mM) was added into the bath solution to increase the viability of preparations. At 24°C, rhythmic SND (recorded from the splanchnic nerve) was consistently observed, but it became quiescent at <16°C. Respiratory-related SND (rSND) was discernible and was well correlated with C4 root activity. Power spectral analysis of SND revealed a dominant 2-Hz oscillation. In most preparations (86%), such oscillation was persistent, whereas it only slightly reduced its magnitude after isolation from the brain stem. The removal of neural structures rostral to the superior cerebellar artery (equivalent to the level of facial nuclei) reduced rSND, increased tonic SND, but did not affect the temporal coupling between SND and C4 root activity. Our data suggest a prominent contribution of SND from the neural mechanisms confined within the neonatal rat spinal cord. This ascorbic acid-enhanced in vitro preparation is a very useful model to study neural mechanisms underlying sympathorespiratory integration.

ascorbic acid; autonomic control; sympathetic development; sympathorespiratory integration


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