Vol. 87, Issue 3, 1038-1047, September 1999
Comparison of the response to histamine challenge of the nose
and the maxillary sinus: effect of loratadine
Fuad M.
Baroody,
Anil
Gungor,
Marcy
deTineo,
Lauran
Haney,
Christopher
Blair, and
Robert M.
Naclerio
Section of Otolaryngology-Head and Neck Surgery, Pritzker School of
Medicine, The University of Chicago, Chicago, Illinois 60637
To study the
response of the maxillary sinus to histamine provocation, we performed
a double-blind, randomized, crossover trial during which nonallergic
subjects without symptoms of rhinitis (n = 25) received either 10 mg
loratadine or placebo once daily for a week and then underwent nasal
challenge with histamine (3, 10, and 30 mg/ml) followed, 24 h later, by
a maxillary sinus challenge while still receiving the medication. Nasal
challenge with histamine led to significant increases in vascular
permeability, reflex nasal secretions, sneezing, and other nasal
symptoms. Sinus challenge resulted in significant increases in vascular
permeability within the sinus cavity
(P < 0.01) and some nasal
symptoms but no significant change in reflex nasal secretions. The
response of the sinus mucosa to histamine was lower in magnitude than
that of the nose. Treatment with loratadine resulted in a significant
inhibition of the histamine-induced changes in both nasal and sinus
cavities. Our data suggest the lack of a sinonasal reflex response to
histamine provocation of the maxillary sinus of nonallergic individuals.
sinonasal reflex; antihistamine; challenge; secretory response
