Journal of Applied Physiology AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 87: 1003-1008, 1999;
8750-7587/99 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bouchard, C.
Right arrow Articles by Rao, D. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bouchard, C.
Right arrow Articles by Rao, D. C.
Vol. 87, Issue 3, 1003-1008, September 1999

Familial aggregation of VO2 max response to exercise training: results from the HERITAGE Family Study

Claude Bouchard1, Ping An2, Treva Rice2, James S. Skinner3, Jack H. Wilmore4, Jacques Gagnon1, Louis Pérusse1, Arthur S. Leon5, and D. C. Rao2,6

1 Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Québec, Canada G1K 7P4; 2 Division of Biostatistics and 6 Department of Genetics and Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110; 3 Department of Kinesiology, Indiana University, Bloomington, Indiana 47405; 4 Department of Health and Kinesiology, Texas A&M University, College Station, Texas 77843; and 5 School of Kinesiology and Leisure Studies, University of Minnesota, Minneapolis, Minnesota 55455

The aim of this study was to test the hypothesis that individual differences in the response of maximal O2 uptake (VO2 max) to a standardized training program are characterized by familial aggregation. A total of 481 sedentary adult Caucasians from 98 two-generation families was exercise trained for 20 wk and was tested for VO2 max on a cycle ergometer twice before and twice after the training program. The mean increase in VO2 max reached ~400 ml/min, but there was considerable heterogeneity in responsiveness, with some individuals experiencing little or no gain, whereas others gained >1.0 l/min. An ANOVA revealed that there was 2.5 times more variance between families than within families in the VO2 max response variance. With the use of a model-fitting procedure, the most parsimonious models yielded a maximal heritability estimate of 47% for the VO2 max response, which was adjusted for age and sex with a maternal transmission of 28% in one of the models. We conclude that the trainability of VO2 max is highly familial and includes a significant genetic component.

trainability; heritability; individuality; family lines


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. Mustelin, K. H. Pietilainen, A. Rissanen, A. R. Sovijarvi, P. Piirila, J. Naukkarinen, L. Peltonen, J. Kaprio, and H. Yki-Jarvinen
Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity
Am J Physiol Endocrinol Metab, July 1, 2008; 295(1): E148 - E154.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. G. Williams and J. P. Folland
Reply from Alun G. Williams and Jonathan P. Folland
J. Physiol., June 15, 2008; 586(12): 3019 - 3020.
[Full Text] [PDF]

Home page
 Diabetes CareHome page
X. Sui, S. P. Hooker, I-M. Lee, T. S. Church, N. Colabianchi, C.-D. Lee, and S. N. Blair
A Prospective Study of Cardiorespiratory Fitness and Risk of Type 2 Diabetes in Women
Diabetes Care, March 1, 2008; 31(3): 550 - 555.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
G. S. Metsios, A. Stavropoulos-Kalinoglou, J. J. C. S. Veldhuijzen van Zanten, G. J. Treharne, V. F. Panoulas, K. M. J. Douglas, Y. Koutedakis, and G. D. Kitas
Rheumatoid arthritis, cardiovascular disease and physical exercise: a systematic review
Rheumatology, March 1, 2008; 47(3): 239 - 248.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
Y. Yi, L. Dongmei, D. A. Phares, E. P. Weiss, J. Brandauer, and J. M. Hagberg
Association between KCNJ11 E23K genotype and cardiovascular and glucose metabolism phenotypes in older men and women
Exp Physiol, January 1, 2008; 93(1): 95 - 103.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. G. Williams and J. P. Folland
Similarity of polygenic profiles limits the potential for elite human physical performance
J. Physiol., January 1, 2008; 586(1): 113 - 121.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
Z. T. Bloomgarden
Diabetes and Obesity: Part 1
Diabetes Care, December 1, 2007; 30(12): 3145 - 3151.
[Full Text] [PDF]

Home page
 Am J EpidemiolHome page
X. Sui, M. J. LaMonte, and S. N. Blair
Cardiorespiratory Fitness as a Predictor of Nonfatal Cardiovascular Events in Asymptomatic Women and Men
Am. J. Epidemiol., June 15, 2007; 165(12): 1413 - 1423.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J. A. Ways, B. M. Smith, J. C. Barbato, R. S. Ramdath, K. M. Pettee, S. J. DeRaedt, D. C. Allison, L. G. Koch, S. J. Lee, and G. T. Cicila
Congenic strains confirm aerobic running capacity quantitative trait loci on rat chromosome 16 and identify possible intermediate phenotypes
Physiol Genomics, March 14, 2007; 29(1): 91 - 97.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. L. Lujan, S. L. Britton, L. G. Koch, and S. E. DiCarlo
Reduced susceptibility to ventricular tachyarrhythmias in rats selectively bred for high aerobic capacity
Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2933 - H2941.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. C. Gonzalez, S. D. Kirkton, R. A. Howlett, S. L. Britton, L. G. Koch, H. E. Wagner, and P. D. Wagner
Continued divergence in VO2 max of rats artificially selected for running endurance is mediated by greater convective blood O2 delivery
J Appl Physiol, November 1, 2006; 101(5): 1288 - 1296.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
R. H.H. Engelbert, M. van Bergen, T. Henneken, P. J.M. Helders, and T. Takken
Exercise Tolerance in Children and Adolescents With Musculoskeletal Pain in Joint Hypermobility and Joint Hypomobility Syndrome
Pediatrics, September 1, 2006; 118(3): e690 - e696.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
S. N. Blair and W. L. Haskell
Objectively measured physical activity and mortality in older adults.
JAMA, July 12, 2006; 296(2): 216 - 218.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
J. Defoor, K. Martens, D. Zielinska, G. Matthijs, H. Van Nerum, D. Schepers, R. Fagard, and L. Vanhees
The CAREGENE study: polymorphisms of the {beta}1-adrenoceptor gene and aerobic power in coronary artery disease
Eur. Heart J., April 1, 2006; 27(7): 808 - 816.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. A. Spruit, R. Gosselink, T. Troosters, A. Kasran, M. Van Vliet, and M. Decramer
Low-Grade Systemic Inflammation and the Response to Exercise Training in Patients With Advanced COPD
Chest, November 1, 2005; 128(5): 3183 - 3190.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. C. Hannukainen, U. M. Kujala, J. Toikka, O. J. Heinonen, J. Kapanen, T. Vahlberg, J. Kaprio, and K. K. Kalliokoski
Cardiac structure and function in monozygotic twin pairs discordant for physical fitness
J Appl Physiol, August 1, 2005; 99(2): 535 - 541.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Lucia, F. Gomez-Gallego, I. Barroso, M. Rabadan, F. Bandres, A. F. San Juan, J. L. Chicharro, U. Ekelund, S. Brage, C. P. Earnest, et al.
PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men
J Appl Physiol, July 1, 2005; 99(1): 344 - 348.
[Abstract] [Full Text] [PDF]

Home page
 Integr. Comp. Biol.Home page
L. G. Koch and S. L. Britton
Divergent Selection for Aerobic Capacity in Rats as a Model for Complex Disease
Integr. Comp. Biol., June 1, 2005; 45(3): 405 - 415.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
C. Di Loreto, C. Fanelli, P. Lucidi, G. Murdolo, A. De Cicco, N. Parlanti, A. Ranchelli, C. Fatone, C. Taglioni, F. Santeusanio, et al.
Make Your Diabetic Patients Walk: Long-term impact of different amounts of physical activity on type 2 diabetes
Diabetes Care, June 1, 2005; 28(6): 1295 - 1302.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. O'Donovan, A. Owen, S. R. Bird, E. M. Kearney, A. M. Nevill, D. W. Jones, and K. Woolf-May
Changes in cardiorespiratory fitness and coronary heart disease risk factors following 24 wk of moderate- or high-intensity exercise of equal energy cost
J Appl Physiol, May 1, 2005; 98(5): 1619 - 1625.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. L. Billat, E. Mouisel, N. Roblot, and J. Melki
Inter- and intrastrain variation in mouse critical running speed
J Appl Physiol, April 1, 2005; 98(4): 1258 - 1263.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. P. Massett and B. C. Berk
Strain-dependent differences in responses to exercise training in inbred and hybrid mice
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R1006 - R1013.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. G. Koch, C. L. Green, A. D. Lee, J. E. Hornyak, G. T. Cicila, and S. L. Britton
Test of the principle of initial value in rat genetic models of exercise capacity
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R466 - R472.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
N. G. Boule, S. J. Weisnagel, T. A. Lakka, A. Tremblay, R. N. Bergman, T. Rankinen, A. S. Leon, J. S. Skinner, J. H. Wilmore, D.C. Rao, et al.
Effects of Exercise Training on Glucose Homeostasis: The HERITAGE Family Study
Diabetes Care, January 1, 2005; 28(1): 108 - 114.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
H. R. Bowles, S. J. FitzGerald, J. R. Morrow Jr., A. W. Jackson, and S. N. Blair
Construct Validity of Self-reported Historical Physical Activity
Am. J. Epidemiol., August 1, 2004; 160(3): 279 - 286.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
P. W. Franks, U. Ekelund, S. Brage, M.-Y. Wong, and N. J. Wareham
Does the Association of Habitual Physical Activity With the Metabolic Syndrome Differ by Level of Cardiorespiratory Fitness?
Diabetes Care, May 1, 2004; 27(5): 1187 - 1193.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J. Rico-Sanz, T. Rankinen, T. Rice, A. S. Leon, J. S. Skinner, J. H. Wilmore, D. C. Rao, and C. Bouchard
Quantitative trait loci for maximal exercise capacity phenotypes and their responses to training in the HERITAGE Family Study
Physiol Genomics, January 15, 2004; 16(2): 256 - 260.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. J. Hautala, T. H. Makikallio, A. Kiviniemi, R. T. Laukkanen, S. Nissila, H. V. Huikuri, and M. P. Tulppo
Cardiovascular autonomic function correlates with the response to aerobic training in healthy sedentary subjects
Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1747 - H1752.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. L. Troxell, S. L. Britton, and L. G. Koch
Genetic Models in Applied Physiology: Selected Contribution: Variation and heritability for the adaptational response to exercise in genetically heterogeneous rats
J Appl Physiol, April 1, 2003; 94(4): 1674 - 1681.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. K. Henderson, H. Wagner, F. Favret, S. L. Britton, L. G. Koch, P. D. Wagner, and N. C. Gonzalez
Determinants of maximal O2 uptake in rats selectively bred for endurance running capacity
J Appl Physiol, October 1, 2002; 93(4): 1265 - 1274.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. F. Feitosa, S. E. Gaskill, T. Rice, T. Rankinen, C. Bouchard, D. C. Rao, J. H. Wilmore, J. S. Skinner, and A. S. Leon
Major gene effects on exercise ventilatory threshold: the HERITAGE Family Study
J Appl Physiol, September 1, 2002; 93(3): 1000 - 1006.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
T. Rankinen, P. An, L. Perusse, T. Rice, Y. C. Chagnon, J. Gagnon, A. S. Leon, J. S. Skinner, J. H. Wilmore, D. C. Rao, et al.
Genome-wide linkage scan for exercise stroke volume and cardiac output in the HERITAGE Family Study
Physiol Genomics, August 14, 2002; 10(2): 57 - 62.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
I. Lerman, B. C. Harrison, K. Freeman, T. E. Hewett, D. L. Allen, J. Robbins, and L. A. Leinwand
Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains
J Appl Physiol, June 1, 2002; 92(6): 2245 - 2255.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
G. F. Fletcher, G. J. Balady, E. A. Amsterdam, B. Chaitman, R. Eckel, J. Fleg, V. F. Froelicher, A. S. Leon, I. L. Pina, R. Rodney, et al.
Exercise Standards for Testing and Training: A Statement for Healthcare Professionals From the American Heart Association
Circulation, October 2, 2001; 104(14): 1694 - 1740.
[Full Text] [PDF]

Home page
 GeneticsHome page
M. R. Dohm, J. P. Hayes, and T. Garland Jr.
The Quantitative Genetics of Maximal and Basal Rates of Oxygen Consumption in Mice
Genetics, September 1, 2001; 159(1): 267 - 277.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. S. Skinner, A. Jaskolski, A. Jaskolska, J. Krasnoff, J. Gagnon, A. S. Leon, D. C. Rao, J. H. Wilmore, and C. Bouchard
Age, sex, race, initial fitness, and response to training: the HERITAGE Family Study
J Appl Physiol, May 1, 2001; 90(5): 1770 - 1776.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
L. G. KOCH and S. L. BRITTON
Artificial selection for intrinsic aerobic endurance running capacity in rats
Physiol Genomics, February 7, 2001; 5(1): 45 - 52.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Rankinen, B. Wolfarth, J.-A. Simoneau, D. Maier-Lenz, R. Rauramaa, M. A. Rivera, M. R. Boulay, Y. C. Chagnon, L. Perusse, J. Keul, et al.
No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status
J Appl Physiol, May 1, 2000; 88(5): 1571 - 1575.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Bouchard, T. Rankinen, Y. C. Chagnon, T. Rice, L. Perusse, J. Gagnon, I. Borecki, P. An, A. S. Leon, J. S. Skinner, et al.
Genomic scan for maximal oxygen uptake and its response to training in the HERITAGE Family Study*
J Appl Physiol, February 1, 2000; 88(2): 551 - 559.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. S. Bray
Genomics, genes, and environmental interaction: the role of exercise
J Appl Physiol, February 1, 2000; 88(2): 788 - 792.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Rankinen, L. Perusse, I. Borecki, Y. C. Chagnon, J. Gagnon, A. S. Leon, J. S. Skinner, J. H. Wilmore, D. C. Rao, and C. Bouchard
The Na+-K+-ATPase alpha 2 gene and trainability of cardiorespiratory endurance: the HERITAGE Family Study
J Appl Physiol, January 1, 2000; 88(1): 346 - 351.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online