Journal of Applied Physiology Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 87: 817-823, 1999;
8750-7587/99 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dwinell, M. R.
Right arrow Articles by Powell, F. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dwinell, M. R.
Right arrow Articles by Powell, F. L.
Vol. 87, Issue 2, 817-823, August 1999

Chronic hypoxia enhances the phrenic nerve response to arterial chemoreceptor stimulation in anesthetized rats

M. R. Dwinell and F. L. Powell

Department of Medicine, University of California, San Diego, La Jolla, California 92093-0623

Chronic exposure to hypoxia results in a time-dependent increase in ventilation called ventilatory acclimatization to hypoxia. Increased O2 sensitivity of arterial chemoreceptors contributes to ventilatory acclimatization to hypoxia, but other mechanisms have also been hypothesized. We designed this experiment to determine whether central nervous system processing of peripheral chemoreceptor input is affected by chronic hypoxic exposure. The carotid sinus nerve was stimulated supramaximally at different frequencies (0.5-20 Hz, 0.2-ms duration) during recording of phrenic nerve activity in two groups of anesthetized, ventilated, vagotomized rats. In the chronically hypoxic group (7 days at 80 Torr inspired PO2), phrenic burst frequency (fR, bursts/min) was significantly higher than in the normoxic control group with carotid sinus nerve stimulation frequencies >5 Hz. In the chronically hypoxic group, peak amplitude of integrated phrenic nerve activity ( int  Phr, percent baseline) or change in int  Phr was significantly greater at stimulation frequencies between 5 and 17 Hz, and minute phrenic activity ( int  Phr × fR) was significantly greater at stimulation frequencies >5 Hz. These experiments show that chronic hypoxia facilitates the translation of arterial chemoreceptor afferent input to ventilatory efferent output through a mechanism in the central nervous system.

hypoxic ventilatory response; acclimatization; central nervous system


This article has been cited by other articles:


Home page
 Integr. Comp. Biol.Home page
R. W. Bavis, F. L. Powell, A. Bradford, C. C.W. Hsia, J. E. Peltonen, J. Soliz, B. Zeis, E. K. Fergusson, Z. Fu, M. Gassmann, et al.
Respiratory plasticity in response to changes in oxygen supply and demand
Integr. Comp. Biol., October 1, 2007; 47(4): 532 - 551.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. D. Kline, A. Ramirez-Navarro, and D. L. Kunze
Adaptive Depression in Synaptic Transmission in the Nucleus of the Solitary Tract after In Vivo Chronic Intermittent Hypoxia: Evidence for Homeostatic Plasticity
J. Neurosci., April 25, 2007; 27(17): 4663 - 4673.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Chung, G. O. Ivy, and S. G. Reid
GABA-mediated neurotransmission in the nucleus of the solitary tract alters resting ventilation following exposure to chronic hypoxia in conscious rats
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1449 - R1456.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. P. Walsh and J. M. Marshall
The early effects of chronic hypoxia on the cardiovascular system in the rat: role of nitric oxide
J. Physiol., August 15, 2006; 575(1): 263 - 275.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. R. Reeves, G. S. Mitchell, and D. Gozal
Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1664 - R1671.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
B. Vulesevic, B. McNeill, and S. F. Perry
Chemoreceptor plasticity and respiratory acclimation in the zebrafish Danio rerio
J. Exp. Biol., April 1, 2006; 209(7): 1261 - 1273.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Donoghue, M. Fatemian, G. M. Balanos, A. Crosby, C. Liu, D. O'Connor, N. P. Talbot, and P. A. Robbins
Ventilatory acclimatization in response to very small changes in PO2 in humans
J Appl Physiol, May 1, 2005; 98(5): 1587 - 1591.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Morelli, M. S. Badr, and J. H. Mateika
Ventilatory responses to carbon dioxide at low and high levels of oxygen are elevated after episodic hypoxia in men compared with women
J Appl Physiol, November 1, 2004; 97(5): 1673 - 1680.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. G. Zabka, G. S. Mitchell, E. B. Olson Jr, and M. Behan
Selected Contribution: Chronic intermittent hypoxia enhances respiratory long-term facilitation in geriatric female rats
J Appl Physiol, December 1, 2003; 95(6): 2614 - 2623.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
O. Ilyinsky, G. Tolstykh, and S. Mifflin
Chronic hypoxia abolishes posthypoxia frequency decline in the anesthetized rat
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2003; 285(6): R1322 - R1330.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. R. Reeves, E. Gozal, S. Z. Guo, L. R. Sachleben Jr., K. R. Brittian, A. J. Lipton, and D. Gozal
Effect of long-term intermittent and sustained hypoxia on hypoxic ventilatory and metabolic responses in the adult rat
J Appl Physiol, November 1, 2003; 95(5): 1767 - 1774.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Izumizaki, M. Tamaki, Y.-i. Suzuki, M. Iwase, T. Shirasawa, H. Kimura, and I. Homma
The affinity of hemoglobin for oxygen affects ventilatory responses in mutant mice with Presbyterian hemoglobinopathy
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2003; 285(4): R747 - R753.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. S. Mitchell and S. M. Johnson
Plasticity in Respiratory Motor Control: Invited Review: Neuroplasticity in respiratory motor control
J Appl Physiol, January 1, 2003; 94(1): 358 - 374.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D D Fuller, Z-Y Wang, L Ling, E B Olson, G E Bisgard, and G S Mitchell
Induced recovery of hypoxic phrenic responses in adult rats exposed to hyperoxia for the first month of life
J. Physiol., November 1, 2001; 536(3): 917 - 926.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Ling, D. D. Fuller, K. B. Bach, R. Kinkead, E. B. Olson Jr, and G. S. Mitchell
Chronic Intermittent Hypoxia Elicits Serotonin-Dependent Plasticity in the Central Neural Control of Breathing
J. Neurosci., July 15, 2001; 21(14): 5381 - 5388.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. S. Mitchell, T. L. Baker, S. A. Nanda, D. D. Fuller, A. G. Zabka, B. A. Hodgeman, R. W. Bavis, K. J. Mack, and E. B. Olson Jr.
Physiological and Genomic Consequences of Intermittent Hypoxia: Invited Review: Intermittent hypoxia and respiratory plasticity
J Appl Physiol, June 1, 2001; 90(6): 2466 - 2475.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
O. A. Alea, M. A. Czapla, J. A. Lasky, N. Simakajornboon, E. Gozal, and D. Gozal
PDGF-beta receptor expression and ventilatory acclimatization to hypoxia in the rat
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2000; 279(5): R1625 - R1633.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online