Journal of Applied Physiology Journal of Applied Physiology
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J Appl Physiol 87: 809-816, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 2, 809-816, August 1999

Oxygen uptake kinetics during exercise are slowed in patients with peripheral arterial disease

Timothy A. Bauer1, Judith G. Regensteiner1,2, Eric P. Brass5, and William R. Hiatt1,3,4

1 Section of Vascular Medicine, Divisions of 2 General Internal Medicine, 3 Geriatrics, and 4 Cardiology, University of Colorado Health Sciences Center, Denver, Colorado 80262; and 5 Department of Medicine, Harbor-UCLA Medical Center, Torrance, California 90509

Patients with peripheral arterial disease (PAD) have arterial occlusions that limit peripheral blood flow. This study evaluated the dynamic response in O2 consumption (VO2) at the onset of constant-load exercise (VO2 kinetics) in patients with PAD. Eight patients with bilateral PAD, seven patients with unilateral PAD, nine age-matched nonsmoking controls, and seven smoking controls performed graded treadmill exercise to assess peak VO2. Subjects also performed constant-load exercise tests at 2.0 miles/h at 0 and 4% grade to determine VO2 kinetics. Peak VO2 was reduced 50% in patients with PAD compared with both control groups (P < 0.05). At 4% grade, phase 2 VO2 kinetics were significantly slowed for the PAD groups compared with controls (60.1 ± 15.7 and 58.7 ± 8.3 s, unilateral and bilateral PAD groups, respectively; compared with 28.4 ± 19.3 and 27.9 ± 8.1 s, nonsmoking and smoking controls, respectively; P < 0.05). No relationship was found between VO2 kinetics and disease severity. These data demonstrate that VO2 kinetics are markedly slowed in patients with PAD. The impairment in VO2 kinetics is not related to smoking status or arterial disease severity and therefore may reflect altered control of skeletal muscle metabolism.

heart rate; oxygen consumption; muscle metabolism


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