Journal of Applied Physiology
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J Appl Physiol 87: 661-672, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 2, 661-672, August 1999

Ventilatory instability during sleep onset in individuals with high peripheral chemosensitivity

Judith Dunai, Jan Kleiman, and John Trinder

Department of Psychology, School of Behavioural Science, University of Melbourne, Parkville, Victoria 3052, Australia

Previous work has shown that the magnitude of state-related ventilatory fluctuations is amplified over the sleep-onset period and that this amplification is partly due to peripheral chemoreceptor activity, because it is reduced by hyperoxia (J. Dunai, M. Wilkinson, and J. Trinder. J. Appl. Physiol. 81: 2235-2243, 1996). These data also indicated considerable intersubject variability in the magnitude of amplification. A possible source of this variability is individual differences in peripheral chemoreceptor drive (PCD). We tested this hypothesis by measuring state-related ventilatory fluctuations throughout sleep onset under normoxic and hyperoxic conditions in subjects with high and low PCD. Results demonstrated that high-PCD subjects experienced significantly greater amplification of state-related ventilatory fluctuations than did low-PCD subjects. In addition, hyperoxia significantly reduced the amplification effect in high-PCD subjects but had little effect in low-PCD subjects. These results indicate that individuals with high PCD are likely to experience greater sleep-related ventilatory instability and suggest that peripheral chemoreceptor activity can contribute to sleep-disordered breathing.

respiratory instability; peripheral chemoreceptors; hypoxic sensitivity; hyperoxia; electroencephalogram


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