| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom
We examined the effect of glycogen-depleting exercise on subsequent muscle total creatine (TCr) accumulation and glycogen resynthesis during postexercise periods when the diet was supplemented with carbohydrate (CHO) or creatine (Cr) + CHO. Fourteen subjects performed one-legged cycling exercise to exhaustion. Muscle biopsies were taken from the exhausted (Ex) and nonexhausted (Nex) limbs after exercise and after 6 h and 5 days of recovery, during which CHO (CHO group, n = 7) or Cr + CHO (Cr+CHO group, n = 7) supplements were ingested. Muscle TCr concentration ([TCr]) was unchanged in both groups 6 h after supplementation commenced but had increased in the Ex (P < 0.001) and Nex limbs (P < 0.05) of the Cr+CHO group after 5 days. Greater TCr accumulation was achieved in the Ex limbs (P < 0.01) of this group. Glycogen was increased above nonexercised concentrations in the Ex limbs of both groups after 5 days, with the concentration being greater in the Cr+CHO group (P = 0.06). Thus a single bout of exercise enhanced muscle Cr accumulation, and this effect was restricted to the exercised muscle. However, exercise also diminished CHO-mediated insulin release, which may have attenuated insulin-mediated muscle Cr accumulation. Ingesting Cr with CHO also augmented glycogen supercompensation in the exercised muscle.
phosphocreatine; insulin; carbohydrate; fatigue
This article has been cited by other articles:
|
|
 |
|
  D. A. Sewell, T. M. Robinson, and P. L. Greenhaff Creatine supplementation does not affect human skeletal muscle glycogen content in the absence of prior exercise J Appl Physiol, February 1, 2008; 104(2): 508 - 512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Derave, N. Straumann, R. A. Olek, and P. Hespel Electrolysis stimulates creatine transport and transporter cell surface expression in incubated mouse skeletal muscle: potential role of ROS Am J Physiol Endocrinol Metab, December 1, 2006; 291(6): E1250 - E1257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. O. Eijnde, W. Derave, J. F. P. Wojtaszewski, E. A. Richter, and P. Hespel AMP kinase expression and activity in human skeletal muscle: effects of immobilization, retraining, and creatine supplementation J Appl Physiol, April 1, 2005; 98(4): 1228 - 1233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-S. Ju, J. L. Smith, P. J. Oppelt, and J. S. Fisher Creatine feeding increases GLUT4 expression in rat skeletal muscle Am J Physiol Endocrinol Metab, February 1, 2005; 288(2): E347 - E352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Tarnopolsky, D. J. Mahoney, J. Vajsar, C. Rodriguez, T. J. Doherty, B. D. Roy, and D. Biggar Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy Neurology, May 25, 2004; 62(10): 1771 - 1777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Ceddia and G. Sweeney Creatine supplementation increases glucose oxidation and AMPK phosphorylation and reduces lactate production in L6 rat skeletal muscle cells J. Physiol., March 1, 2004; 555(2): 409 - 421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Derave, B. O. Eijnde, P. Verbessem, M. Ramaekers, M. Van Leemputte, E. A. Richter, and P. Hespel Combined creatine and protein supplementation in conjunction with resistance training promotes muscle GLUT-4 content and glucose tolerance in humans J Appl Physiol, May 1, 2003; 94(5): 1910 - 1916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Walzel, O. Speer, E. Boehm, S. Kristiansen, S. Chan, K. Clarke, J. P. Magyar, E. A. Richter, and T. Wallimann New creatine transporter assay and identification of distinct creatine transporter isoforms in muscle Am J Physiol Endocrinol Metab, August 1, 2002; 283(2): E390 - E401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kong, P. N. Shepel, C. P. Holden, M. Mackiewicz, A. I. Pack, and J. D. Geiger Brain Glycogen Decreases with Increased Periods of Wakefulness: Implications for Homeostatic Drive to Sleep J. Neurosci., July 1, 2002; 22(13): 5581 - 5587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Persky and G. A. Brazeau Clinical Pharmacology of the Dietary Supplement Creatine Monohydrate Pharmacol. Rev., May 11, 2001; (2001) 1. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. O.'t Eijnde, B. Ursø, E.A. Richter, P.L. Greenhaff, and P. Hespel Effect of Oral Creatine Supplementation on Human Muscle GLUT4 Protein Content After Immobilization Diabetes, January 1, 2001; 50(1): 18 - 23. [Abstract] [Full Text]
|
|
|
|
|
|
A. M. Persky and G. A. Brazeau Clinical Pharmacology of the Dietary Supplement Creatine Monohydrate Pharmacol. Rev., June 1, 2001; 53(2): 161 - 176. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
