| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Istituto di Fisiologia Umana I, Università di Milano, 20133 Milan, Italy
Diffusional permeability
(P) to water
(Pw),
Cl
(PCl
),
and mannitol
(Pman) was
determined in specimens of rabbit parietal pericardium without and with
phospholipids added on the luminal side, as previously done with
sucrose and Na+.
P to the above-mentioned molecules and
to Na+
(PNa+)
was also determined after mesothelium was scraped away from specimens.
Pw,
PCl, PNa+,
and Pman of
connective tissue were the following
(×105 cm/s): 73.1 ± 7.3 (SE), 59.5 ± 4.5, 41.7 ± 3.4, and 23.4 ± 2.4, respectively. From these and corresponding data on integer pericardium, Pw,
PCl,
PNa+, and Pman of
mesothelium were computed. They were the following: 206, 17.9, 9.52, and 3.93, and 90.2, 14.4, 4.34, and 1.75 × 105
cm/s without and with phospholipids, respectively. As previously found
for P to sucrose,
P to solutes is smaller in mesothelium than in connective tissue, although the latter is ~35-fold thicker; instead, Pw is
higher in mesothelium, suggesting marked water diffusion through cell
membrane. Equivalent radius of paracellular "pores" of
mesothelium was computed with two approaches, disregarding Pw. The former, a
graphical analysis on a P-molecular
radius diagram, yielded 6.0 and 1.7 nm without and with phospholipids,
respectively. The latter, on the basis of
Pman,
P to sucrose, and function for restricted diffusion, yielded 7.8 and 1.1 nm, respectively.
connective tissue; diffusional permeability to water and small solutes; pericardium; phospholipids
This article has been cited by other articles:
|
|
 |
|
  P. D. Jobsis, H. Ashikaga, H. Wen, E. C. Rothstein, K. A. Horvath, E. R. McVeigh, and R. S. Balaban The visceral pericardium: macromolecular structure and contribution to passive mechanical properties of the left ventricle Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3379 - H3387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. LAI-FOOK Pleural Mechanics and Fluid Exchange Physiol Rev, April 1, 2004; 84(2): 385 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Zocchi Physiology and pathophysiology of pleural fluid turnover Eur. Respir. J., December 1, 2002; 20(6): 1545 - 1558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Bodega, L. Zocchi, and E. Agostoni Albumin transcytosis in mesothelium Am J Physiol Lung Cell Mol Physiol, January 1, 2002; 282(1): L3 - L11. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Bodega, L. Zocchi, and E. Agostoni Macromolecule transfer through mesothelium and connective tissue J Appl Physiol, December 1, 2000; 89(6): 2165 - 2173. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
