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Departments of 1 Human Services, 2 Medicine, 3 Health Evaluation Sciences, and 4 Pediatrics, University of Virginia, Charlottesville, Virginia 22908
To investigate the effects of exercise intensity on growth
hormone (GH) release, 10 male subjects were tested on 6 randomly ordered occasions [1 control condition (C), 5 exercise conditions (Ex)]. Serum GH concentrations were measured in samples obtained at 10-min intervals between 0700 and 0900 (baseline) and 0900 and 1300 (exercise+ recovery). Integrated GH concentrations (IGHC) were
calculated by trapezoidal reconstruction. During Ex subjects exercised
for 30 min (0900-0930) at one of the following intensities [normalized to the lactate threshold (LT)]: 25 and 75% of
the difference between LT and rest (0.25LT and 0.75LT, respectively), at LT, and at 25 and 75% of the difference between LT and peak (1.25LT
and 1.75LT, respectively). No differences were observed among
conditions for baseline IGHC. Exercise+recovery IGHC (mean ± SE: C = 250 ± 60; 0.25LT = 203 ± 69; 0.75LT = 448 ± 125; LT = 452 ± 119; 1.25LT = 512 ± 121; 1.75LT = 713 ± 115 µg · l
1 · min1)
increased linearly with increasing exercise intensity
(P < 0.05). Deconvolution analysis
revealed that increasing exercise intensity resulted in a linear
increase in the mass of GH secreted per pulse and GH production rate
[production rate increased from 16.5 ± 4.5 (C) to 32.1 ± 5.2 µg · distribution
volume1 · min1
(1.75LT), P < 0.05], with no
changes in GH pulse frequency or half-life of elimination. We conclude
that the GH secretory response to exercise is related to exercise
intensity in a linear dose-response pattern in young men.
lactate threshold; endocrinology; pituitary; somatotropin
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