Journal of Applied Physiology
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J Appl Physiol 87: 491-497, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 2, 491-497, August 1999

Postpneumonectomy alveolar growth does not normalize hemodynamic and mechanical function

Shin-Ichi Takeda1, Murugappan Ramanathan1, Aaron S. Estrera2, and Connie C. W. Hsia1

Departments of 1 Medicine and 2 Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9034

Immature foxhounds underwent 55% lung resection by right pneumonectomy (n = 5) or thoracotomy without pneumonectomy (Sham, n = 6) at 2 mo of age. Cardiopulmonary function was measured during treadmill exercise on reaching maturity 1 yr later. In pneumonectomized animals compared with Sham animals, maximal oxygen uptake, ventilatory response, and cardiac output during exercise were normal. Arterial and mixed venous blood gases and arteriovenous oxygen extraction during exercise were also normal. Mean pulmonary arterial pressure and resistance were elevated at a given cardiac output. Dynamic ventilatory power requirement was also significantly elevated at a given minute ventilation. These long-term hemodynamic and mechanical abnormalities are in direct contrast to the normal pulmonary gas exchange during exercise in these same pneumonectomized animals reported elsewhere (S. Takeda, C. C. W. Hsia, E. Wagner, M. Ramanathan, A. S. Estrera, and E. R. Weibel. J. Appl. Physiol. 86: 1301-1310, 1999). Functional compensation was superior in animals pneumonectomized as puppies than as adults. These data indicate a limited structural response of conducting airways and extra-alveolar pulmonary blood vessels to pneumonectomy and suggest the development of other sources of adaptation such as those involving the heart and respiratory muscles.

exercise; pulmonary arterial pressure; pulmonary arterial resistance; arteriovenous oxygen extraction; ventilatory power output; work of breathing; lung resection; dog


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